Psychiatry Investig.  2020 Jan;17(1):21-28. 10.30773/pi.2019.0105.

Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia

• Lee D
• Kim BJ
• Han JW
• Kim TH
• Kwak KP
• Kim K
• Kim SG
• Kim JL
• Kim TH
• Moon SW
• Park JY
• Park JH
• Byun S
• Suh SW
• Seo JY
• So Y
• Ryu SH
• Youn JC
• Lee KH
• Lee DY
• Lee DW
• Lee SB
• Lee JJ
• Lee JR
• Jeong H
• Jeong HG
• Jhoo JH
• Han K
• Hong JW
• Bae JB
• Kim KW

• KMID: 2501474
• DOI: http://doi.org/10.30773/pi.2019.0105

Abstract

Objective
Cardiovascular diseases are representative risk factors for the onset of cognitive decline. The purpose of this study was to confirm the relationship between diastolic blood pressure and cognitive function in elderly people in Korea.
Methods
Data from subjects who were enrolled in the prospective Korean Longitudinal Study on Cognitive Aging and Dementia were used in this study. Data from 701 subjects whose diastolic blood pressure range did not change (≤79 mm Hg or ≥80 mm Hg) over 2 years were analyzed. To analyze the differences in cognitive function between the groups at the 2-year follow-up, an analysis of covariance was performed with covariates, which were significantly different between the two groups, and the baseline cognitive function.
Results
Significant differences were observed between the two groups, and the mean scores on the constructional praxis (η²=0.010) and word list recall tests (η²=0.018) in the diastolic blood pressure ≥80 mm Hg group were higher than those in the diastolic blood pressure ≤79 mm Hg group at the 2-year follow-up.
Conclusion
These results indicate that maintaining a DBP below 79 mm Hg presents a greater risk of cognitive decline in Korean elderly people.

Keyword

Cognition, Diastolic blood pressure, Senility