Clin Exp Otorhinolaryngol.  2020 Feb;13(1):69-76. 10.21053/ceo.2019.00388.

Evaluation of Prognostic Factors for the Parotid Cancer Treated With Surgery and Postoperative Radiotherapy

• Kim YH
• Chung WK
• Jeong JU
• Cho IJ
• Yoon MS
• Song JY
• Nam TK
• Ahn SJ
• Lee DH
• Yoon TM
• Lee JK
• Lim SC

• KMID: 2501301
• DOI: http://doi.org/10.21053/ceo.2019.00388

Abstract

Objectives
. To investigate the prognostic factors and treatment outcomes of primary parotid carcinoma treated with surgery and postoperative radiotherapy (PORT).
Methods
. We reviewed retrospectively 57 patients with primary parotid carcinoma who were treated with surgery and PORT between 2005 and 2014. Superficial parotidectomy was performed in 19 patients, total parotidectomy in 10 patients, and total parotidectomy with lymph node dissection in 28 patients PORT on the tumor bed was performed in 41 patients, while PORT on tumor bed and ipsilateral cervical lymph nodes was performed in 16 patients.
Results
. With a median follow-up of 66 months, the 5-year overall survival, disease-free survival, locoregional control, and distant control rates were 77.0%, 60.2%, 77.6%, and 72.8%, respectively. The 5-year overall survival by stage was 100%, 100%, 80.0%, and 46.4% in stage I, II, III, and IV, respectively. Recurrences at primary lesions were found in seven patients, while at cervical nodes in six patients. Distant recurrences were developed in 12 patients. No patient with the low and intermediate histologic grade developed distant failure. As prognostic factors, the histologic grade for overall survival (P=0.005), pathological T-stage (P=0.009) and differentiation grade (P=0.009) for disease-free survival, pathological T-stage for locoregional control (P=0.007), and lympho-vascular invasion (P=0.023) for distant recurrence were significant on multivariate analysis.
Conclusion
. This study revealed that differentiation grade, histologic grade, pathological T-stage, and lympho-vascular invasion were significant independent prognostic factors on clinical outcomes.

Keyword

Parotid Neoplasms; Adjuvant Radiotherapy; Prognosis; Metastases

Figure

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  Fig. 1. Overall survival (OS) and disease-free survival (DFS) rates for 57 patients with parotid gland carcinoma.

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  Fig. 2. Locoregional control (LRC) and distant control (DC) rates for 57 patients with parotid gland carcinoma.

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  Fig. 3. Treatment failure patterns after postoperative radiotherapy with parotid gland carcinoma. Of 22 patients of failures, seven (12.3%) of local, six (10.5%) of regional, and 12 (21.1%) of distant failure were observed, respectively.

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