Cancer Res Treat.  2020 Apr;52(2):438-445. 10.4143/crt.2019.313.

Loss of Heterozygosity at Chromosome 16q Is a Negative Prognostic Factorin Korean Pediatric Patients with Favorable Histology Wilms Tumor:A Report of the Korean Pediatric Hematology Oncology Group (K-PHOG)

• Park JE
• Noh OK
• Lee Y
• Choi HS
• Han JW
• Hahn SM
• Lyu CJ
• Lee JW
• Yoo KH
• Koo HH
• Jeong SY
• Sung KW

• KMID: 2500329
• DOI: http://doi.org/10.4143/crt.2019.313

Abstract

Purpose
Loss of heterozygosity (LOH) at chromosomes 1p and 16q is a poor prognostic factor in favorable histology Wilms tumor (FHWT). This study investigated the prevalence of LOH at 1p and 16q and evaluated its prognostic value in Korean children with FHWT.
Materials and Methods
We analyzed 101 FHWT patients who were diagnosed between 1996 and 2016 in Korean Society of Pediatric Hematology Oncology Group hospitals. Using paraffin-embedded kidney tissue samples sent from each center, we reviewed LOH at 1p and 16q in each patient and assessed the prognostic value of LOH status for clinical parameters affecting event-free survival (EFS).
Results
Of the 101 patients, 12 (11.9%) experienced recurrence; the 3-year EFS was 87.6%. LOH at 1p or 16q was detected in 19 patients (18.8%), with five having LOH at both 1q and 16q. The frequency of LOH at 1p was higher among younger patients (p=0.049), but there was no difference in LOH prevalence according to tumor stage. In the multivariate analysis, LOH at 16q was a significant negative prognostic factor affecting EFS (3-year EFS, 73.7% vs. 91.1%; hazard ratio, 3.95; p=0.037), whereas LOH at 1p was not (p=0.786).
Conclusion
LOH at 16q was a significant negative prognostic factor affecting outcome in Korean pediatric FHWT patients. Due to the small sample size of this study, large-scale multicenter trials are warranted to investigate the prognostic value of LOH at 1p and 16q in Korean children with FHWT.

Keyword

Wilms tumor; Loss of heterozygosity; 16q; 1p; Survival; Prognosis

Figure

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  Fig. 1. Event-free survival rates according to loss of heterozygosity (LOH) at 1p (A) and 16q (B) and four groups classified as 1p only, 16q only, none, and both (C).

Reference

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