Clin Exp Otorhinolaryngol.  2020 May;13(2):194-202. 10.21053/ceo.2019.01634.

The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis

• Ahn SH
• Kim WS

• KMID: 2500293
• DOI: http://doi.org/10.21053/ceo.2019.01634

Abstract

Objectives
. Hemithyroidectomy is commonly performed in patients with low- to intermediate-risk papillary thyroid carcinoma. The purpose of this meta-analysis was to evaluate the effect of prophylactic central neck dissection on locoregional recurrence in patients undergoing hemithyroidectomy.
Methods
. A meta-analysis was performed of full-text publications published in English retrieved from the Embase database.
Results
. The rate of regional recurrence in the central compartment after hemithyroidectomy, with or without prophylactic central neck dissection, was 0.17% and 1.78%, respectively. This difference was statistically significant. Recurrence in the lateral compartment or contralateral thyroid was not affected by prophylactic central neck dissection; the overall rate of recurrence was 1.3% and 5.4%, respectively.
Conclusion
. Prophylactic central neck dissection significantly reduced the risk of recurrence in the central compartment in patients undergoing hemithyroidectomy.

Keyword

Central Neck Dissection; Locoregional Recurrence; Papillary Thyroid Carcinoma; Thyroidectomy; Lymph Node

Figure

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  Fig. 1. Flow diagram illustrating the literature search protocol. CND, central neck dissection.

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  Fig. 2. Risk of bias summary according to the risk of bias assessment tool for non-randomized studies.

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  Fig. 3. Proportional analysis of recurrence after lobectomy with or without central neck dissection. Comparisons of recurrence in the central compartment (A), recurrence in the lateral compartment (B). CI, confidence interval; CND, central neck dissection. Continued. Proportional analysis of recurrence after lobectomy with or without central neck dissection. (C) Comparison of recurrence in the contralateral thyroid. CI, confidence interval; CND, central neck dissection.

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