J Korean Soc Emerg Med.  2020 Apr;31(2):146-151.

Effect of vasopressin on prognosis in sepsis shock

• Kim S
• Lee KH
• Min MK
• Ryu JH
• Lee DS
• Lee MJ
• Wang IJ

Abstract

Objective
This study analyzed the relationship between the timing of vasopressin treatment and the prognosis of patients with septic shock.
Methods
Patients who were admitted to a university hospital for one year using vasopressin were studied retrospectively. All records were collected through the medical records; several factors were studied to determine the prognosis of the patient. The 24-hour, 48-hour mortality, and hospital mortality were examined. The difference in the timing of vasopressin administration between death and survival patients was analyzed to determine the effect of the vasopressor on the survival rate using the receiver operating characteristic (ROC) curve.
Results
The general characteristics of the patients in the hospital and survivors were similar. Vasopressin infusion was faster in the surviving patients than in the death patients, but there was no significant difference (survival, 187.0 minutes; interquartile range [IQR], 95.0-548.0 minutes vs. death, 285.5 minutes; IQR, 92.7-739.2). To determine the effect of vasopressor injection on the survival rate, the ROC curve was drawn, and the area under curve was not affected significantly by norepinephrine (NE) 0.416 and vasopressin 0.529. In addition, the duration of the ventilator application was found to increase with increasing NE injection period in survivors (period of application of ventilator: NE injection time, r=0.460, P=0.048; vasopressin, r=0.369, P=0.120).
Conclusion
The prognosis was similar regardless of the timing of vasopressin in patients with septic shock.

Keyword

Vasopressin; Septic shock; Norepinephrine; Mortality