Nucl Med Mol Imaging.  2020 Apr;54(2):105-113. 10.1007/s13139-020-00634-x.

Radioactivity Reduction of 2-Deoxy-2-[18F] Fluoro-D-Glucose by Milkand Ursodeoxycholic Acid in Preclinical Study

• Jeong HJ
• Bagalkot TR
• Kim HS
• Han YH
• Kim M
• Lim ST
• Sohn MH

• KMID: 2500064
• DOI: http://doi.org/10.1007/s13139-020-00634-x

Abstract

Purpose
2-Deoxy-2-[18F] fluoro-d-glucose positron emission tomography (18F-FDG-PET) is a less-invasive and widely used diagnostic tool for detection of malignant tumors. However, prolonged retention of 18F-FDG in the body increases radiation exposure. This study evaluated the effect of oral administration of milk and ursodeoxycholic acid (UDCA) in terms of reducing radiation exposure by 18F-FDG.
Methods
18F-FDG radioactivity was measured using a digital γ counter in the whole body and in various organs of rats after oral administration of milk andmilk plusUDCA (milk + UDCA).Western blotting was performed to measure the expression levels of G6Pase, HK 2, CREB, FoxO1, and PGC-1α in the brain, liver, small intestine, and large intestine to assess the mechanism underlying the reduction in radiation exposure from 18F-FDG by oral administration of milk and UDCA.
Results
We found a significant reduction in 18F-FDG radioactivity in the whole body and in the brain, liver, and small and large intestines. Expression of G6Pase was significantly increased in the above-mentioned organs in the milk and milk + UDCA groups. Expression of HK 2 was significantly decreased in the brain and small intestine in the milk and milk + UDCA groups. CREB, FoxO1, and PGC-1α expression levels in the brain, liver, and small intestine were increased in the milk and milk + UDCA groups. However, expression of PGC-1α in the large intestine in the milk and milk + UDCA groups was significantly decreased compared with that in the control group.
Conclusion
The present study demonstrated that administration of milk and UDCA increased G6Pase expression levels and 18FFDG release from the tissue. These results suggest milk and UDCA could be used to reduce radiation exposure from 18F-FDG after image acquisition. The mechanisms underpinning this phenomenon should be explored in a human study.

Keyword

2-Deoxy-2-[18F] fluoro-d-glucose; Ursodeoxycholic acid; Milk; Radioactivity