J Rheum Dis.  2020 Jan;27(1):73-74. 10.4078/jrd.2020.27.1.73.

A Case of Acute Lymphoblastic Leukemia Presenting as Unilateral Sternoclavicular Joint Arthritis and Mass

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, National Medical Center, Seoul, Korea.
  • 2Department of Pathology, Jeju National University School of Medicine, Jeju, Korea.
  • 3Division of Rheumatology, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. slera@yahoo.com

Abstract

No abstract available.


MeSH Terms

Arthritis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Sternoclavicular Joint*

Figure

  • Figure 1 Magnetic resonance imaging demonstrated focal cortical disruption at anterior mid aspect of right distal clavicle and decreased bone marrow signal intensity on T1 image, and right sternoclavicular joint arthritis, which suggested septic arthritis with osteomyelitis or malignancy (A~C, arrows).

  • Figure 2 Bone biopsy of right distal clavicle revealed increased atypical cell infiltration with necrosis, which was consistent with leukemic infiltration (A, H&E stain, ×400, arrows). The bone marrow biopsy showed nearly packed marrow with myelofibrosis (B, H&E stain, ×400, arrowheads).


Reference

1. Kubota H, Saida S, Kouzuki K, Hamabata T, Daifu T, Kato I, et al. [Pediatric acute lymphoblastic leukemia presenting with bone and joint pain]. Rinsho Ketsueki. 2018; 59:167–173. Japanese.
2. Pécheux L, Forget P, Geurten C, Rausin L, Nicolescu R, Hoyoux C. [Bone disorders and complications of pediatric acute lymphoblastic leukemia : monocentric study and review of the literature]. Rev Med Liege. 2018; 73:575–582. French.
3. Rehman A, Abbas N, Saba T, Rahman SIU, Mehmood Z, Kolivand H. Classification of acute lymphoblastic leukemia using deep learning. Microsc Res Tech. 2018; 81:1310–1317.
Article
4. Tragiannidis A, Vasileiou E, Papageorgiou M, Damianidou L, Hatzipantelis E, Gombakis N, et al. Bone involvement at diagnosis as a predictive factor in children with acute lymphoblastic leukemia. Hippokratia. 2016; 20:227–230.
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