Yonsei Med J.  2020 Apr;61(4):331-340. 10.3349/ymj.2020.61.4.331.

Local Injection of Growth Hormone for Temporomandibular Joint Osteoarthritis

Affiliations
  • 1Department of Oral Medicine, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Korea. drcookie@pusan.ac.kr
  • 2Department of Oral Medicine, Dental and Life Science Institute, Pusan National University School of Dentistry, Yangsan, Korea.
  • 3Department of Microbiology & Immunology, Pusan National University School of Medicine, Yangsan, Korea.
  • 4Department of Oral Pathology, Pusan National University School of Dentistry, Yangsan, Korea.
  • 5Deptartment of Oral Medicine, Busan Paik Hospital, Inje University, Busan, Korea.

Abstract

PURPOSE
Osteoarthritis (OA) of the temporomandibular joint (TMJ) elicits cartilage and subchondral bone defects. Growth hormone (GH) promotes chondrocyte growth. The aim of this study was to evaluate the efficacy of intra-articular injections of GH to treat TMJ-OA.
MATERIALS AND METHODS
Monosodium iodoacetate (MIA) was used to induce OA in the TMJs of rats. After confirming the induction of OA, recombinant human GH was injected into the articular cavities of rats. Concentrations of GH and IGF-1 were measured in the blood and synovial fluid, and OA grades of cartilage and subchondral bone degradation were recorded by histological examination and micro-computed tomography.
RESULTS
MIA-induced OA in the rat TMJ upregulated insulin-like growth factor-1 (IGF-1) rather than GH levels. GH and IGF-1 concentrations were increased after local injection of GH, compared with controls. Locally injected GH lowered osteoarthritic scores in the cartilage and subchondral bone of the TMJ.
CONCLUSION
Intra-articular injection of GH improved OA scores in rat TMJs in both cartilage and subchondral bone of the condyles without affecting condylar bone growth. These results suggest that intra-articular injection of human GH could be a suitable treatment option for TMJ-OA patients in the future.

Keyword

temporomandibular joint; osteoarthritis; intraarticular injection; Growth hormone

MeSH Terms

Animals
Bone Development
Cartilage
Chondrocytes
Growth Hormone*
Humans
Injections, Intra-Articular
Insulin-Like Growth Factor I
Osteoarthritis*
Rats
Synovial Fluid
Temporomandibular Joint*
Growth Hormone
Insulin-Like Growth Factor I
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