Ann Surg Treat Res.  2020 Mar;98(3):116-123. 10.4174/astr.2020.98.3.116.

Prognostic factors predicting survival rate over 10 years of patients with intrahepatic cholangiocarcinoma after hepatic resection

• Ma CH
• Hwang DW
• Song KB
• Kim SC
• Shin SH
• Lee JH

• KMID: 2471176
• DOI: http://doi.org/10.4174/astr.2020.98.3.116

Abstract

PURPOSE
Hepatic resection is considered as the optimal treatment for intrahepatic cholangiocarcinoma (IHCC); however, the survival rate after resection is low and the analysis of long-term (≥10 years) survivors is rare. This study aims to analyze the clinicopathological factors affecting the long-term survival of patients with IHCC.
METHODS
Between January 2003 and December 2012, a single-institution cohort of 429 patients who underwent hepatic resection for IHCC were reviewed retrospectively. Surgical results, recurrence, and survival rates were investigated, and multivariate analyses were performed to identify prognostic factors.
RESULTS
The overall 1- , 3- , 5- and 10-year survival rates of patients were 76.5%, 44.1%, 33.3%, and 25.1%, respectively. Multivariate analysis showed that the serum CA 19-9 level (≥38 U/mL) (P < 0.001), lymph node (LN) metastasis (P = 0.001), and lymphovascular invasion (LVI) (P = 0.012) were independent factors associated with overall survival. In particular, CA 19-9 level and histologic type were determined to be independent factors affecting survival for more than 10 years.
CONCLUSION
CA 19-9 (≥38 U/mL), LN metastasis, and LVI were identified as independent risk factors for survival after resection of IHCC. CA 19-9 (<38 U/mL) and histologic type were independent factors predicting survival for more than 10 years.

Keyword

Bile ducts; Cholangiocarcinoma; Prognosis; Survival analysis

MeSH Terms

Bile Ducts
Cholangiocarcinoma*
Cohort Studies
Humans
Lymph Nodes
Multivariate Analysis
Neoplasm Metastasis
Prognosis
Recurrence
Retrospective Studies
Risk Factors
Survival Analysis
Survival Rate*
Survivors

Figure

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  Fig. 1 Kaplan-Meier survival curves. (A) Cumulative survival rate after curative resection. (B) Cumulative recurrence rate after curative resection.

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  Fig. 2 (A) The results of Kaplan-Meier analysis of patients who survived over 10 years and below 10 years according to the CA 19-9 level. (B) The results of Kaplan-Meier analysis of patients who survived over 10 years and below 10 years according to the histopathological type.

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