Korean J Health Promot.  2019 Dec;19(4):196-201. 10.15384/kjhp.2019.19.4.196.

The Relationship between Pulmonary Function and Serum Uric Acid Level in the Korean Population

• Kim GT
• Sull JW

• KMID: 2469166
• DOI: http://doi.org/10.15384/kjhp.2019.19.4.196

Abstract

BACKGROUND
Forced vital capacity (FVC), forced expiratory volume in the first second (FEV₁), and the ratio of FEV₁ to FVC (FEV₁/FVC) are considered as the major spirometry parameters. Serum uric acid is associated with increased risk of gout and cardiovascular disease. We analyzed the relationship between pulmonary function and serum uric acid level in the Korean men and women.
METHODS
This study was based on the data collected during the 2016 Korea National Health and Nutrition Examination Survey (KNHANES VII-1). A total of 3,411 adults were retrieved from KNHANES VII-1. Among 3,411 adults, 1,500 were men and 1,911 were women.
RESULTS
In this study, a significant negative correlation was observed between serum uric acid level and pulmonary function values only in females. Also, in the male non-smoker group, pulmonary function values were negatively associated with serum uric acid level (FVC %predicted, β=−0.014; FEV₁ %predicted, β=−0.015).
CONCLUSIONS
In this study, hyperuricemia was associated with the low lung function in males and females. In order to obtain an accurate assessment of the association between hyperuricemia and pulmonary function values, further prospective cohort study in the future is necessary.

Keyword

Uric acid; Lung diseases; Hyperuricemia; Vital capacity; Forced expiratory volume

MeSH Terms

Adult
Cardiovascular Diseases
Cohort Studies
Female
Forced Expiratory Volume
Gout
Humans
Hyperuricemia
Korea
Lung
Lung Diseases
Male
Nutrition Surveys
Prospective Studies
Spirometry
Uric Acid*
Vital Capacity
Uric Acid

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