Perinatology.  2019 Dec;30(4):193-199. 10.14734/PN.2019.30.4.193.

Perinatal Outcomes Following Prolonged Preterm Premature Rupture of Membranes before Limit of Viability - A Single Center Experience

• Lee NH
• Park JH
• Bae JG

• KMID: 2468539
• DOI: http://doi.org/10.14734/PN.2019.30.4.193

Abstract

OBJECTIVE
To investigate maternal and neonatal outcomes following prolonged preterm premature rupture of membrane (PPROM) before limit of viability in a single center.
METHODS
Thirty-two women with PPROM before 25 weeks' gestation without overt intrauterine infection were administered expectant management. We investigated maternal and neonatal outcomes of pregnancies following PPROM occurring before 25 weeks' gestation and with latent period (from membrane rupture to delivery) of 7 days or more.
RESULTS
Median gestational age at membrane rupture was 22.1 weeks. Median latent period was 32 days. Median gestational age at delivery was 26.6 weeks. The incidence of clinical pulmonary hypoplasia and early onset sepsis was 43.5% (10/23) and 21.7% (5/23), respectively. The overall mortality in neonatal intensive care unit (NICU) was 43.5% (10/23). Latent period was negatively correlated with gestational age at membrane rupture (r=−0.501, P=0.015), but not associated with maternal complications. As the length of latent period increased, overall mortality in NICU decreased (relative risk=0.898, P=0.011).
CONCLUSION
The expectant management in women with PPROM before 25 weeks' gestation did not induce maternal complications and might help to improve the neonatal outcomes rather than the immediate delivery.

Keyword

Fetal membranes, premature rupture; Pregnancy maintenance; Pregnancy complications; Infant mortality

MeSH Terms

Female
Fetal Membranes, Premature Rupture
Gestational Age
Humans
Incidence
Infant
Infant Mortality
Infant, Newborn
Intensive Care, Neonatal
Membranes*
Mortality
Pregnancy
Pregnancy Complications
Pregnancy Maintenance
Rupture*
Sepsis

Figure

• 

  Fig. 1. Flowchart of pregnant women and infants with PPROM before 25 weeks of gestation. PPROM, prolonged preterm premature rupture of membrane; GA, gestaional age; NICU, neonatal intensive care unit.

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