Infect Chemother.  2016 Sep;48(3):199-208. 10.3947/ic.2016.48.3.199.

Mortality Risk Factors for Patients with Septic Shock after Implementation of the Surviving Sepsis Campaign Bundles

Affiliations
  • 1Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
  • 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. SERAN@yuhs.ac
  • 3AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Septic shock remains a leading cause of death, despite advances in critical care management. The Surviving Sepsis Campaign (SSC) has reduced morbidity and mortality. This study evaluated risk factors for mortality in patients with septic shock who received treatment following the SSC bundles.
MATERIALS AND METHODS
This retrospective cohort study included patients with septic shock who received treatments following SSC bundles in an urban emergency department between November 2007 and November 2011. Primary and secondary endpoints were all-cause 7- and 28-day mortality.
RESULTS
Among 436 patients, 7- and 28-day mortality rates were 7.11% (31/436) and 14% (61/436), respectively. In multivariate analysis, high lactate level (odds ratio [OR], 1.286; 95% confidence interval [CI], 1.016-1.627; P=0.036) and low estimated glomerular filtration rate (OR, 0.953; 95% CI, 0.913-0.996; P=0.032) were independent risk factors for 7-day mortality. Risk factors for 28-day mortality were high lactate level (OR, 1.346; 95% CI, 1.083-1.673; P=0.008) and high Acute Physiology and Chronic Health Evaluation II score (OR, 1.153; 95% CI, 1.029-1.293; P=0.014).
CONCLUSION
The risk of mortality of septic shock patients remains high in patients with high lactate levels and acute kidney injury.

Keyword

Septic shock; Risk factors; Mortality

MeSH Terms

Acute Kidney Injury
APACHE
Cause of Death
Cohort Studies
Critical Care
Emergency Service, Hospital
Glomerular Filtration Rate
Humans
Lactic Acid
Mortality*
Multivariate Analysis
Retrospective Studies
Risk Factors*
Sepsis*
Shock, Septic*
Lactic Acid

Cited by  2 articles

Lactate as a Biomarker for Sepsis Prognosis?
Ha Eun Kang, Dae Won Park
Infect Chemother. 2016;48(3):252-253.    doi: 10.3947/ic.2016.48.3.252.

Effects of Early Exercise Rehabilitation on Functional Recovery in Patients with Severe Sepsis
Jin Young Ahn, Je Eun Song, Hea Won Ann, Yongduk Jeon, Mi Young Ahn, In Young Jung, Moo Hyun Kim, Wooyoung Jeong, Su Jin Jeong, Nam Su Ku, June Myung Kim, Sungwon Na, Sung-Rae Cho, Jun Yong Choi
Yonsei Med J. 2018;59(7):843-851.    doi: 10.3349/ymj.2018.59.7.843.


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