J Korean Soc Radiol.  2019 Nov;80(6):1203-1213. 10.3348/jksr.2019.80.6.1203.

MRI Criteria for Predicting Invasive Lesions in Biopsy-Proven Ductal Carcinoma in Situ

Affiliations
  • 1Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. claudel@skku.edu
  • 2Department of Radiology, Ewha Womans University Seoul Hospital, Seoul, Korea.
  • 3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

PURPOSE
To evaluate the criteria for predicting invasive lesions with preoperative breast MRI in ductal carcinoma in situ (DCIS) histopathologically diagnosed with biopsy.
MATERIALS AND METHODS
We retrospectively analyzed the preoperative MRI findings of 80 percutaneous biopsy-proven DCIS. The morphological type, enhancement distribution and kinetics, and extent of the lesions were analyzed. We compared the results of pure DCIS and DCIS with invasive lesions. We evaluated the MRI criteria for predicting DCIS with invasive lesions and assessed its diagnostic performance.
RESULTS
Of the 80 DCIS lesions analyzed, 27 contained co-existing invasive lesions and 49 were pure DCIS. No residual lesions after biopsy were seen in 4 cases. DCIS with invasive lesions showed washout kinetics more frequently and to a larger extent than did pure DCIS (p = 0.030 and p = 0.048, respectively). Using enhancement kinetics and the lesion cut-off value of 4 cm yielded the highest diagnostic performance, with 92.6% sensitivity and 93.8% negative predictive value for predicting invasive lesions.
CONCLUSION
Washout kinetics and the lesion extent of at least 4 cm are useful criteria for the prediction of co-existing invasive lesions in patients with DCIS diagnosed with biopsy.


MeSH Terms

Biopsy
Breast
Carcinoma, Ductal*
Carcinoma, Intraductal, Noninfiltrating*
Humans
Kinetics
Magnetic Resonance Imaging*
Retrospective Studies
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