J Korean Radiol Soc.  1981 Sep;17(2):187-192. 10.3348/jkrs.1981.17.2.187.

An experimental study on radiation hepatitis

• Kang IW
• Park CI
• Kim CW

• KMID: 2463392
• DOI: http://doi.org/10.3348/jkrs.1981.17.2.187

Abstract

The effect of radiation on the liver should be of unusual interest in as much as there are two highly specialized kinds of epithelium besides an important endothelial system and vascular and fibrous elements tocompare, But there are several difficulites in the way of knowledge of the sensitivity and reaction of the liverto radiation. Perhaps the most important is the regenerative abillity of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necrosis of the liverin man resulting from doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in resum enezymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The resuls obtained are asfollows; 1. Serum SGOT activities were significatnly elevated, 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation, and normalized after4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation, and normalized after 8 weeks. 4. Histopathologic changes were focal necrosis, inflammatory cell infiltration, loss of intra cytoplasmic glycogen particles, and vacuolar degenerations of hepatocytes. It appeared marked 2 weeks after irradiation, restored after 4 weeks, and normalized after 8 weeks.

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Cytoplasm
Epithelium
Glycogen
Hepatitis*
Hepatocytes
Liver
Necrosis
Radiation Injuries
Skin
Stomach
Alanine Transaminase
Aspartate Aminotransferases
Glycogen