J Korean Ophthalmol Soc.  2019 Nov;60(11):1117-1120. 10.3341/jkos.2019.60.11.1117.

Primary Amyloidosis Localized to the Conjunctiva

  • 1Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea. ophkoh@hanmail.net


To report a case of primary amyloidosis localized to the conjunctiva.
A 19-year-old male with a conjunctival mass and foreign body sensations in the right eye transferred from another hospital. A 0.5 × 2.5 cm reddish mass was present in the medial canthus of the right conjunctiva with no other clinically specific signs. Surgical excisional biopsy was performed. Histological examination showed amyloid deposition. There was no other orbital involvement apart from the conjunctiva. Abnormalities were not found in the systemic examination.
We report a case of primary amyloidosis localized to the conjunctiva.


Amyloidosis; Biopsy; Conjunctival neoplasm

MeSH Terms

Conjunctival Neoplasms
Foreign Bodies
Lacrimal Apparatus
Plaque, Amyloid
Young Adult


  • Figure 1 Slit-lamp photograph on the first visit. A reddish diffuse protruding mass in the medial canthal conjunctiva in the right eye (arrow) (A). Surgical excisional biopsy was performed, and the specimen size was 0.5 × 2.5 × 0.2 cm (B).

  • Figure 2 Histological features of the conjunctival mass. A hematoxylin and eosin (H&E)-stained section showed amorphous, homogenous, eosinophilic material composed of amyloid (arrows). (A) H&E staining (×200). (B) H&E staining (×400).

  • Figure 3 Histological features of the conjunctival mass. A Congo-red-stained section shows orange colored stained amyloid deposits (arrows). (A) Congo red staining (×100). (B) Congo red staining (×400).

  • Figure 4 Slit-lamp photograph at the 6 months after operation. The mass was completely removed, with no recurrence.


1. Westermark P, Benson MD, Buxbaum JN, et al. Amyloid fibril protein nomenclature -- 2002. Amyloid. 2002; 9:197–200.
2. Moorman CM, McDonald B. Primary (localised non-familial) conjunctival amyloidosis: three case reports. Eye (Lond). 1997; 11:603–606.
3. Kim B, Song JH, Yang SW, Kim MS. A case of bilateral conjunctival amyloidosis treated with mass excision and cryotherapy. J Korean Ophthalmol Soc. 2011; 52:628–632.
4. Lee HM, Naor J, DeAngelis D, Rootman DS. Primary localized conjunctival amyloidosis presenting with recurrence of subconjunctival hemorrhage. Am J Ophthalmol. 2000; 129:245–247.
5. Demirci H, Shields CL, Eagle RC Jr, Shields JA. Conjunctival amyloidosis: report of six cases and review of the literature. Surv Ophthalmol. 2006; 51:419–433.
6. Aryasit O, Preechawai P, Kayasut K. Clinical presentation, treatment, and prognosis of periocular and orbital amyloidosis in a university-based referral center. Clin Ophthalmol. 2013; 7:801–805.
7. Caggiati A, Campanella A, Tenna S, et al. Primary amyloidosis of the eyelid: a case report. In Vivo. 2010; 24:575–578.
8. Stephen P. Ginsberg. The cornea in systemic disease. In : Tasman W, Jaeger EA, editors. Duane's Clinical Ophthalmology. revised ed. Philadelphia: JB Lippincott;2006. v. 5. chap. 43.
9. Matthews AE. Wills resident case series. Review of Ophthalmology 2010. Accessed June 27, 2019. https://www.reviewofophthalmology.com/article/wills-resident-case-series.
10. Mesa-Gutiérrez JC, Huguet TM, Garcia NB, Ginebreda JA. Primary localized conjunctival amyloidosis: a case report with a ten-year follow-up period. Clin Ophthalmol. 2008; 2:685–687.
11. Rosenblatt M, Spitz GF, Friedman AH, Kazam ES. Localized conjunctival amyloidosis: case reports and review of literature. Ophthalmologica. 1986; 192:238–245.
12. Choi HJ, Choung HK, Khwarg SI. Primary localized amyloidosis of the lacrimal gland. J Korean Ophthalmol Soc. 2004; 45:1567–1572.
13. Kang YS, Choi W, Yoon KC. Primary systemic amyloidosis of the eyelid: a case report. J Korean Ophthalmol Soc. 2015; 56:1117–1121.
14. Fraunfelder FW. Liquid nitrogen cryotherapy for conjunctival amyloidosis. Arch Ophthalmol. 2009; 127:645–648.
15. Song BR, Kim YK, Yoo JH, Chu YC. Primary localized amyloidosis of bulbar conjunctiva and cornea. J Korean Ophthalmol Soc. 1993; 34:352–356.
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