J Korean Radiol Soc.  1983 Dec;19(4):776-779. 10.3348/jkrs.1983.19.4.776.

Correlation of hepatocellular-scintigraphic findings with HBe antigenecity in chronic hepatitis B

• Song KS
• Chun KS
• Chung SK
• Bahk YW

• KMID: 2463105
• DOI: http://doi.org/10.3348/jkrs.1983.19.4.776

Abstract

Radioimmunoassay plays an important role in diagnosing the hepatitis B and in clinical asssessement of thecourse of the disease as well. Among a number of antigens, antibodies and enzymes related with hepatitis, HBe Ag,DNA polymerase, IgM-HBc-antibody, delta Ag have been known as useful indicators of ongoing infectivity ofhepatitis B. The present study has been undertaken to correlate the HBe antigenecity withhepatospleno-sintigraphic findings in hepatitis. The study covered a 10 month period from Sept. 1982 through toJuly 1983. We reviewed and analyzed the hepatospleno-scintigraphic findings and the results of radioimmuassays in32 patients of chronic hepatitis seen at St. Mary's Hospital, Catholoic Medical College. Hepatitis B was diagnosedeither when HBs Ag was positive or Anti-HBc was positive even if HBs Ag was negative. We classified the HBeantigenecity into two groups of HBe Ag(+) and HBe(-) and analyzed the scintigraphic findings in terms of liversize, mottling, splenomegaly and splenic shift. From the present study, it is concluded that the activity ofhepatitis B can not be assessed by the findings of hepatospleno-scintigram so far as the activity is determined onthe basis of the positive HBe Ag, which has been believed to indicate continuing viral replication.

MeSH Terms

Antibodies
Hepatitis
Hepatitis B
Hepatitis B, Chronic*
Hepatitis, Chronic*
Humans
Liver
Radioimmunoassay
Splenomegaly
Antibodies