J Korean Radiol Soc.  1986 Feb;22(1):1-11. 10.3348/jkrs.1986.22.1.1.

An experimental study on hepatic artery embolization with absolute ethanol

• Kim KH
• Park JH
• Kang HS
• Im JG
• Han MC
• Kim CW

• KMID: 2462362
• DOI: http://doi.org/10.3348/jkrs.1986.22.1.1

Abstract

The hepatic artery was embolized with absolute ethanol in 1 mongrel dogs to evaluate the embolic effect andsafety of this material. Follow up angiography and liver function test were performed at 15 minutes, 1 week and 4weeks after embolization. Retrograde cholangiography, microangiography and pathologic examination were done at 4weeks after embolization. The result was as follows: 1. Sequential angiography showed successful and persistentocclusion of intrahepatic arteries at different levels, and reconstitution of the intrahepatic arterialcirculation via collaterals. 2. Microangiography revealed avascular area in 5 cases. But in incompletely infactedare there showed tortuous hepatic arteries, decreased perfusion of sinusoid and microcolaterals through theinterlobular arteries, capsular arteries and peribiliary vascular plexus. In one case sparse peribiliary plexuswas observed. 3. Retrograde cholangiography revealed findings of cholangitis on involved segment. 4. The absoluteethanol was effective for achieving a permanent occlusion of intraheptaic arteries but caused damage on sinusoidand hepatic parenchyme, and on peribilary vasucular plexus resulting in sclerosing cholangitis. So in furtherclinical application, caution would be necessary to superselect the tumor supplying artery to avoid unnecessaryparenchymal damage.

MeSH Terms

Angiography
Animals
Arteries
Cholangiography
Cholangitis
Cholangitis, Sclerosing
Dogs
Ethanol*
Follow-Up Studies
Hepatic Artery*
Liver Function Tests
Perfusion
Ethanol