Cancer Res Treat.  2019 Oct;51(4):1269-1274. 10.4143/crt.2018.604.

Atezolizumab in Patients with Pretreated Urothelial Cancer: a Korean Single-Center, Retrospective Study

• Hur JY
• Kim Y
• Kwon GY
• Kang M
• Sung HH
• Jeon HG
• Jeong BC
• Seo SI
• Jeon SS
• Lee HM
• Lee SJ
• Park SH

• KMID: 2460576
• DOI: http://doi.org/10.4143/crt.2018.604

Abstract

PURPOSE
Treatment targeting immune checkpoint with programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors has demonstrated efficacy and tolerability in the treatment of metastatic urothelial carcinoma (mUC). We investigated the efficacy and safety of atezolizumab in mUC patients who failed platinum-based chemotherapy.
MATERIALS AND METHODS
A retrospective study using the Samsung Medical Center cancer chemotherapy registry was performed on 50 consecutive patients with mUC treated with atezolizumab, regardless of their PD-L1(SP142) status, as salvage therapy after chemotherapy failure between May 2017 and June 2018. Endpoints included overall response rate (RR), progression-free survival (PFS), and safety.
RESULTS
Among 50 patients, men constituted 76% and the median age was 68 years (range, 46 to 82 years). Twenty-three patients (46%) received atezolizumab as second-line therapy. PD-L1 (SP142) status IC0/1 and IC2/3 were found in 21 (42%) and 21 (42%) of patients, respectively; in eight patients (16%), PD-L1 (SP142) expression was not available. Atezolizumab was generally well tolerated, with pruritus and fatigue being the most commonly observed toxicities. As a result, partial response was noted in 20 patients (40%), with 12 (24%) stable diseases. RRwas higherin IC2/3 (62%) than in IC0/1 patients (24%, p=0.013). The median PFS was 7.4 months (95% confidence interval, 3.4 to 11.4 months). As expected, PFS also was significantly longer in IC2/3 patients than in IC0/1 (median, 12.7 vs. 2.1 months; p=0.005). PFS was not significantly influenced by age, sex, performance status, number of previous chemotherapy, site of metastases, or any of the baseline laboratory parameters.
CONCLUSION
In this retrospective study, atezolizumab demonstrated clinically efficacy and tolerability in unselected mUC patients who failed platinum-based chemotherapy.

Keyword

Atezolizumab; Salvage; Urothelial carcinoma; Retrospective

MeSH Terms

Disease-Free Survival
Drug Therapy
Fatigue
Humans
Male
Neoplasm Metastasis
Pruritus
Retrospective Studies*
Salvage Therapy

Figure

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  Fig. 1. Percentages of best response to atezolizumab for patients with programmed death-ligand 1 (PD-L1) expression < 5% or unknown (blue line, n=29) and those with PD-L1 expression > 5% or higher (red line, n=21). IC, immune cell.

• 

  Fig. 2. Kaplan-Meier plots of progression-free survival (PFS) for all patients (blue line), patients programmed death-ligand 1 (PD-L1) expression < 5% or unknown (red line), and those with PD-L1 expression > 5% or higher (green line). IC, immune cell.

Reference

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