J Korean Med Sci.  2019 Oct;34(40):e260. 10.3346/jkms.2019.34.e260.

Effect of Institutional Kidney Transplantation Case-Volume on Post-Transplant Graft Failure: a Retrospective Cohort Study

• Oh HW
• Jang EJ
• Kim GH
• Yoo S
• Lee H
• Lim TY
• Kim H
• Ryu HG

• KMID: 2460036
• DOI: http://doi.org/10.3346/jkms.2019.34.e260

Abstract

BACKGROUND
The impact of institutional case volume to graft failure rate after adult kidney transplantation is relatively unclear compared to other solid organ transplantations.
METHODS
A retrospective cohort study of 13,872 adult kidney transplantations in Korea was performed. Institutions were divided into low- (< 24 cases/year), medium- (24-60 cases/year), and high- (> 60 cases/year) volume centers depending on the annual case volume. One-year graft failure rate was defined as the proportion of patients who required dialysis or re-transplantation at one year after transplantation. Postoperative in-hospital mortality and long-term graft survival were also measured.
RESULTS
After adjustment, one year graft failure was higher in low-volume centers significantly (adjusted odds ratio [aOR], 1.50; 95% confidence interval [CI], 1.26-1.78; P < 0.001) and medium-volume centers (aOR, 1.87; 95% CI, 1.57-2.23; P < 0.001) compared to high-volume centers. Low-volume centers had significantly higher mortality (aOR, 1.75; 95% CI, 1.15-2.66; P = 0.01) than that of high-volume centers after adjustment. Long-term graft survival of up to 9 years was superior in high-volume centers compared to low- and medium-volume centers (P < 0.001).
CONCLUSION
Higher-case volume centers were associated with lower one-year graft failure rate, lower in-hospital mortality, and higher long-term graft survival after kidney transplantation.

Keyword

Kidney Transplantation; Case-Volume; One-Year Graft Failure; Mortality

MeSH Terms

Adult
Cohort Studies*
Dialysis
Graft Survival
Hospital Mortality
Humans
Kidney Transplantation*
Kidney*
Korea
Mortality
Odds Ratio
Organ Transplantation
Retrospective Studies*
Transplants*