Perinatology.  2019 Sep;30(3):147-153. 10.14734/PN.2019.30.3.147.

Clinical Study of 31 Polydactyly Cases Admitted to Neonatal Intensive Care Unit

• Lee Y
• Gang M
• Chang M
• Song W
• Kim S

• KMID: 2460028
• DOI: http://doi.org/10.14734/PN.2019.30.3.147

Abstract

OBJECTIVE
To investigate polydactyly in neonates who were admitted to neonatal intensive care unit (NICU) due to urgent medical needs.
METHODS
Retrospective chart review of polydactyly neonates admitted to NICU of Chungnam National University Hospital between September 1997 and September 2018 was carried out. Patient data, type of polydactyly accompanying anomalies, genetic testing and clinical follow-up after discharge were reviewed and analyzed.
RESULTS
Thirty-one neonates with polydactyly were admitted to NICU during the selected period. 61.3% were male. Most were admitted for the evaluation and treatment for other congenital anomalies. Ten neonates (32%) were small for gestational age. The most frequently observed forms of polydactyly were preaxial hand polydactyly and postaxial foot polydactyly. Cardiac anomalies (35%) were more frequent in the population than genitourinary tract anomalies (22%), central nervous system anomalies (22%), gastrointestinal tract anomalies (19%) and congenital hypothyroidism. Four neonates showed abnormal genetic finding. Three neonates were diagnosed syndromic disorder after discharge (CATCH22 syndrome, VACTERL association, Joubert syndrome). Pregnancy of these neonates was complicated by maternal diabetes (13%), hepatitis B virus (6%), exposure to herbal medicine or smoking (6%), pre-eclampsia and hypertension. Only one case in the study had positive family history for polydactyly.
CONCLUSION
Polydactyly could serve as a clue to syndromes and genetic disorders if associated with multiple major organ anomalies.

Keyword

Newborn; Polydactyly; Anomaly

MeSH Terms

Central Nervous System
Chungcheongnam-do
Clinical Study*
Congenital Hypothyroidism
Follow-Up Studies
Foot
Gastrointestinal Tract
Genetic Testing
Gestational Age
Hand
Hepatitis B virus
Herbal Medicine
Humans
Hypertension
Infant, Newborn
Intensive Care, Neonatal*
Male
Polydactyly*
Pre-Eclampsia
Pregnancy
Retrospective Studies
Smoke
Smoking
Smoke