Korean J Dermatol.
2019 Aug;57(7):399-402.
Cutaneous Angiosarcoma of the Foot Accompanied by Multiple Myeloma: The First Case Report
- Affiliations
-
- 1Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, Korea. cykim@gnu.ac.kr
- 2Department of Dermatology, Gyeongsang Institute of Health Science, Jinju, Korea.
Abstract
- Although the exact etiology of cutaneous angiosarcoma remains unclear, MYC gene amplification has been recently discovered as a new pathogenesis. MYC is a proto-oncogene, and aberration of MYC signaling in malignancies is associated with tumor metastasis, recurrence, and mortality. Moreover, upregulation of the miRNA polycistron, miR-17-92 cluster, were confirmed in both cutaneous angiosarcoma and multiple myeloma with MYC amplification. The correlation between MYC and miRNA expression is predictable as the coincident aberrant phenotype in two diseases. Moreover, the exploiting MYC dependency may be an attractive disease-specific strategy for the diagnosis and treatment of patients who are unaware of the causes of cutaneous angiosarcoma. Herein, a rare case of cutaneous angiosarcoma of the foot, which is also the first case of cutaneous angiosarcoma accompanied by multiple myeloma, has been described.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Cutaneous Plasmacytoma Treated with Thalidomide
- Necrobiotic Xanthogranuloma with Multiple Myeloma and No Periorbital Involvement
- Huge Cutaneous Involvement of Multiple Myeloma
- A Case of Multiple Myeloma First Presenting as Cutaneous Plasmacytoma
- A Case of Cutaneous Plasmacytoma Treated with Bortezomib and Radiotherapy
