J Cardiovasc Imaging.  2019 Jul;27(3):200-211. 10.4250/jcvi.2019.27.e26.

Comparison of Left Ventricular Volumes Measured by 3DE, SPECT and CMR

• Beitner N
• Jenner J
• Sörensson P

• KMID: 2456855
• DOI: http://doi.org/10.4250/jcvi.2019.27.e26

Abstract

BACKGROUND
Information regarding left ventricular (LV) volume and left ventricular ejection fraction (LVEF) has major diagnostic and prognostic value when assessing patients after ST-elevation myocardial infarction (STEMI). We aimed to investigate the agreement between measurement of LV volumes and LVEF by three-dimensional echocardiography (3DE), single-photon emission computed tomography (SPECT) and cardiac magnetic resonance (CMR) imaging in patients in a stable phase after STEMI.
METHODS
Fifteen patients underwent examinations by 3DE, SPECT and CMR three months after STEMI.
RESULTS
There was a significant bias in end-diastolic volume (EDV) measured by 3DE (-64 mL, p < 0.001) and SPECT (-55 mL, p < 0.001) compared with that measured by CMR. This was also the case for end-systolic volume (ESV) measured by 3DE (-36 mL, p < 0.001) and SPECT (-28 mL, p < 0.001). No significant differences were found between 3DE and SPECT for EDV or ESV. However, LVEF did not differ between the three methods. The agreement between all three methods was moderate (intra-class correlation coefficient [ICC] = 0.44) for LV volume and good for LVEF (ICC = 0.72).
CONCLUSIONS
LV volumes assessed by 3DE did not differ from SPECT, and despite larger LV volumes by CMR, measurements of LVEF showed good agreement between all three methods.

Keyword

Left ventricular function; Myocardial infarction; Three-dimensional echocardiography; Magnetic resonance imaging; Single-photon emission-computed tomography

MeSH Terms

Bias (Epidemiology)
Echocardiography, Three-Dimensional
Humans
Magnetic Resonance Imaging
Myocardial Infarction
Stroke Volume
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon*
Ventricular Function, Left

Figure

• 

  Figure 1 Examples of short-axis (top) and long axis (bottom) cut planes with endocardial tracings in images acquired by CMR (A), 3DE (B) and SPECT (C) demonstrating the difference in the ability to identify LV trabeculations. All images are acquired from the same study patient. Traces are somewhat enhanced to increase readability. 3DE: three-dimensional echocardiography, CMR: cardiac magnetic resonance imaging, LV: left ventricle, SPECT: single-photon emission computed tomography.

• 

  Figure 2 Bland–Altman plot of agreement between CMR and SPECT (A), CMR and 3DE (B) and SPECT and 3DE (C) for measurement of EDV. The solid line represents the mean difference, and the dashed lines represent the 95% confidence interval. 3DE: three-dimensional echocardiography, CMR: cardiac magnetic resonance imaging, EDV: end-diastolic volume, SPECT: single-photon emission computed tomography.

• 

  Figure 3 Bland–Altman plot of agreement between CMR and SPECT (A), CMR and 3DE (B) and SPECT and 3DE (C) for measurement of ESV. The solid line represents the mean difference, and the dashed lines represent the 95% confidence interval. 3DE: three-dimensional echocardiography, CMR: cardiac magnetic resonance imaging, ESV: end-systolic volume, SPECT: single-photon emission computed tomography.

• 

  Figure 4 Bland–Altman plot of agreement between CMR and SPECT (A), CMR and 3DE (B) and SPECT and 3DE (C) for measurement of LVEF. The solid line represents the mean difference, and the dashed lines represent the 95% confidence interval. 3DE: three-dimensional echocardiography, CMR: cardiac magnetic resonance imaging, LVEF: left ventricular ejection fraction, SPECT: single-photon emission computed tomography.

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