Diabetes Metab J.  2019 Aug;43(4):521-529. 10.4093/dmj.2018.0080.

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study

• Namkung J
• Sohn JH
• Chang JS
• Park SW
• Kim JY
• Koh SB
• Kong ID
• Park KS

• KMID: 2455674
• DOI: http://doi.org/10.4093/dmj.2018.0080

Abstract

BACKGROUND
Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory roles. This study investigated the association between serum ANGPTL6 levels and new-onset metabolic syndrome.
METHODS
In total, 221 participants without metabolic syndrome were randomly selected from a rural cohort in Korea. Baseline serum ANGPTL6 levels were measured using an enzyme-linked immunosorbent assay. Anthropometric and biochemical markers were analyzed before and after follow-up examinations.
RESULTS
During an average follow-up period of 2.75 (interquartile range, 0.76) years, 82 participants (37.1%) presented new-onset metabolic syndrome and had higher ANGPTL6 levels before onset than those without metabolic syndrome (48.03±18.84 ng/mL vs. 64.75±43.35 ng/mL, P=0.001). In the multivariable adjusted models, the odds ratio for the development of metabolic syndrome in the highest quartile of ANGPTL6 levels was 3.61 (95% confidence interval, 1.27 to 10.26). The use of ANGPTL6 levels in addition to the conventional components improved the prediction of new-onset metabolic syndrome (area under the receiver operating characteristic curve: 0.775 vs. 0.807, P=0.036).
CONCLUSION
Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome.

Keyword

ANGPTL6 protein, human; Biomarkers; Metabolic syndrome; Prospective studies; ROC curve

MeSH Terms

Biomarkers
Cohort Studies*
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Glucose
Korea
Lipoproteins
Metabolic Diseases
Odds Ratio
Prospective Studies*
ROC Curve
Triglycerides
Biomarkers
Glucose
Lipoproteins

Figure

• 

  Fig. 1 Receiver operating characteristic curve analysis of angiopoietin-like 6 (ANGPTL6). (A) Model 1: baseline high density lipoprotein cholesterol, triglyceride, waist circumference, blood pressure, and glucose levels. (B) Model 2: Model 1+sex and age. AUC, area under the curve; CI, confidence interval.

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