Asian Spine J.  2019 Aug;13(4):527-534. 10.31616/asj.2018.0166.

Quantitative Predictive Imaging Biomarkers of Lumbar Intervertebral Disc Degeneration

• Vadapalli
• Mulukutla
• Vadapalli
• Vedula RR

• KMID: 2455641
• DOI: http://doi.org/10.31616/asj.2018.0166

Abstract

STUDY DESIGN: Observational comparative study. PURPOSE: To compare fractional anisotropy (FA) maps with T2 values of the nucleus pulposus (NP) and annulus fibrosus (AF) of intervertebral discs in healthy volunteers and patients to develop a predictive disc health scale. OVERVIEW OF LITERATURE: T2-weighted magnetic resonance imaging (MRI) is not sensitive to early morphological changes and provides no quantitative biomarker profile for early degeneration.
METHODS
We examined 59 healthy controls and 59 patients with back pain by MRI using T2 relaxometry and diffusion tensor imaging (DTI). Each group was divided into three age subgroups: A (<30 years, n=12); B (30-50 years, n=26); and C (>50 years, n=21). We obtained FA values for AF and NP and T2 values for NP for each intervertebral disc. Furthermore, we calculated the FA (AF/NP) ratios.
RESULTS
We categorized 590 intervertebral discs from 118 participants, 566 of which were analyzed with T2 relaxometry and DTI. The T2 values were as follows: subgroup A, 55.8±4.4 ms; B, 48.5±6.9 ms; C, 45.8±8.7 ms (p<0.050). The T2 values for the healthy controls of the subgroups A, B, and C were >120 ms, 90-100 ms, and 70 ms, respectively (p<0.001). Control subgroup A had higher T2 values and AF/NP ratios than subgroups B and C; the AF values were not significantly different. Control subgroup B had higher T2 values and AF/NP ratios than subgroup C but lower FA (NP).
CONCLUSIONS
FA maps of the AF/NP ratio and T2 values of NP are potential microstructure biomarkers of normal and degenerating discs and can help detect early degeneration using a predictive disc health score on a continuous scale.

Keyword

Annulus fibrosus; Diffusion tensor imaging; Fractional anisotropy; Nucleus pulposus; T2 relaxometry

MeSH Terms

Anisotropy
Back Pain
Biomarkers*
Diffusion Tensor Imaging
Healthy Volunteers
Humans
Intervertebral Disc Degeneration*
Intervertebral Disc*
Magnetic Resonance Imaging
Biomarkers