Nucl Med Mol Imaging.  2019 Aug;53(4):242-246. 10.1007/s13139-019-00603-z.

Theranostics Based on Liposome: Looking Back and Forward

• Lee W
• Im HJ

• KMID: 2455518
• DOI: http://doi.org/10.1007/s13139-019-00603-z

Abstract

Liposome is one of the oldest yet most successful nanomedicine platforms. Doxil®, PEGylated liposome loaded with doxorubicin (DOX), was approved by the FDA in 1995 for the treatment of AIDS-related Kaposi's sarcoma, and it was the first approval for nanomedicine. Since then, liposome-based therapeutics were approved for the treatment of various diseases and many clinical trials are underway. The success of the liposome-based therapeutics was due to following factors: (1) ease of synthesis, (2) biocompatibility, (3) the ability to load both hydrophilic and hydrophobic agents, and (4) long circulation property after application of polyethylene glycol (PEG). Recently, more functionalities are introduced to liposome platform, which are (1) in vivo imaging probes for optical, magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT), (2) pH and temperature-sensitive lipid moiety, and (3) novel agents for photodynamic and photothermal therapies (PDT, PTT). These conventional and newly tested advantages make the liposome to be one of the most promising nanoplatforms for theranostics.

Keyword

Liposome; Theranostics; Nanomedicine; Controlled drug release

MeSH Terms

Doxorubicin
Hydrogen-Ion Concentration
Liposomes*
Magnetic Resonance Imaging
Nanomedicine
Polyethylene Glycols
Positron-Emission Tomography
Sarcoma, Kaposi
Theranostic Nanomedicine*
Tomography, Emission-Computed
Doxorubicin
Liposomes
Polyethylene Glycols