Korean J Ophthalmol.  2019 Aug;33(4):379-385. 10.3341/kjo.2018.0094.

Location of Retinal Nerve Fiber Layer Defects in Open-angle Glaucoma and Associated Factors

Affiliations
  • 1Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. eyena@kdh.or.kr

Abstract

PURPOSE
To investigate the location of retinal nerve fiber layer defects (RNFLDs) in open-angle glaucoma and the differences in systemic and ocular factors between superotemporal and inferotemporal RNFLDs.
METHODS
We performed a retrospective review of the 2008 to 2012 data from the Korea National Health and Nutrition Examination Survey. Subjects aged ≥19 years with an evaluable fundus photograph of at least one eye were enrolled, and open-angle glaucoma was diagnosed according to modified International Society of Geographical and Epidemiological Ophthalmology criteria. In subjects with open-angle glaucoma, locations of RNFLDs were evaluated, and systemic and ocular factors were compared between the bilateral superotemporal RNFLD group and bilateral inferotemporal RNFLD group.
RESULTS
A total of 534 subjects had open-angle glaucoma with RNFLDs. The unilateral inferotemporal region (25.8%) was the most common location for RNFLDs, followed by the unilateral superotemporal region (24.4%). Multivariate analysis revealed that hypertension was more significantly associated (p = 0.048) with the bilateral superotemporal RNFLD group than with the bilateral inferotemporal RNFLD group.
CONCLUSIONS
Superotemporal RNFLDs are more related to hypertension than are inferotemporal RNFLDs.

Keyword

Hypertension; Korea National Health and Nutrition Examination Survey; Open-angle glaucoma; Retinal nerve fiber layer defect

MeSH Terms

Glaucoma, Open-Angle*
Hypertension
Korea
Multivariate Analysis
Nerve Fibers*
Nutrition Surveys
Ophthalmology
Retinaldehyde*
Retrospective Studies
Retinaldehyde

Figure

  • Fig. 1 Participation flow chart from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008 to 2012. ISGEO = International Society of Geographical and Epidemiological Ophthalmology; FDT = frequency-doubling technology.


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