Ann Clin Neurophysiol.  2019 Jul;21(2):105-107. 10.14253/acn.2019.21.2.105.

Acute unilateral isolated abducens nerve palsy associated with anti-GM1 immunoglobulin M antibody

Affiliations
  • 1Department of Neurology, Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. koodaelim@gmail.com

Abstract

Acute ophthalmoparesis that includes the oculomotor, trochlear, or abducens nerve may occur as an initial presentation of Miller Fisher syndrome (MFS). The symptoms of MFS or variant forms of Guillain-Barre syndrome are pathogenically related to anti-GQ1b antibodies. We report a case of a 36-year-old man with unilateral isolated abducens nerve palsy associated with anti-GM1 antibody. To the best of our knowledge, this is the first report of unilateral isolated abducens nerve palsy with positivity for anti-GM1 immunoglobulin M antibody.

Keyword

Abducens nerve; Ophthalmoplegia; Immunoglobulins

MeSH Terms

Abducens Nerve Diseases*
Abducens Nerve*
Adult
Antibodies
Guillain-Barre Syndrome
Humans
Immunoglobulin M*
Immunoglobulins*
Miller Fisher Syndrome
Ophthalmoplegia
Antibodies
Immunoglobulin M
Immunoglobulins

Figure

  • Fig. 1 Isolated abducens nerve palsy of the left eye. Lancaster tests illustrated an isolated abduction deficit of the left eye (paralytic strabismus). Red bars (the dotted line box from closed arrow) indicate normal positions of the right eye during left conjugate gaze. Green bars (the dotted line box from open arrow) represent abnormal positions of the left eye, which are deviated from red bars during left conjugate gaze.


Cited by  1 articles

Isolated facial diplegia variant of Guillain–Barré syndrome with anti-GM1 IgG antibody
Jin Ho Jung, Sukyoon Lee, Jung Hwa Seo, Jong Seok Bae, Kyong Jin Shin, Jong Kuk Kim, Byeol-A Yoon, Seong-il Oh
Ann Clin Neurophysiol. 2022;24(1):17-20.    doi: 10.14253/acn.2022.24.1.17.


Reference

1. Chou KL, Galetta SL, Liu GT, Volpe NJ, Bennett JL, Asbury AK, et al. Acute ocular motor mononeuropathies: prospective study of the roles of neuroimaging and clinical assessment. J Neurol Sci. 2004; 219:35–39.
Article
2. Odaka M, Yuki N, Hirata K. Anti-GQ1b IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry. 2001; 70:50–55.
Article
3. Kaida K, Ariga T, Yu RK. Antiganglioside antibodies and their pathophysiological effects on Guillain-Barre syndrome and related disorders--a review. Glycobiology. 2009; 19:676–692.
Article
4. Willison HJ, Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain. 2002; 125(Pt 12):2591–2625.
Article
5. Lavallée P, Vidailhet M, Dussaule JC, Derkinderen P. Post-infectious ophtalmoparesis associated with anti-GM1 but not with anti-GQ1b antibodies. Eur J Neurol. 2001; 8:475–476.
Article
6. Go T. Partial oculomotor nerve palsy associated with elevated anti-galactocerebroside and anti-GM1 antibodies. J Pediatr. 2000; 137:425–426.
Article
7. Han TH, Kim DY, Park DW, Moon JH. Transient isolated lower bulbar palsy with elevated serum anti-GM1 and anti-GD1b antibodies during aripiprazole treatment. Pediatr Neurol. 2017; 66:96–99.
Article
8. Fusco C, Bertani G, Scarano A, Giustina ED. Acute ophthalmoparesis associated with anti-GM1, anti-GD1a, and anti-GD1b antibodies after enterovirus infection in a 6-year-old girl. J Child Neurol. 2007; 22:432–434.
Article
9. Katchanov J, Lünemann JD, Masuhr F, Meisel A, Möller H, Zschenderlein R. Isolated abducens nerve paresis associated with high titer of anti-asialo-GM1 following Campylobacter jejuni enteritis. J Neurol. 2004; 251:1404–1405.
Article
10. Caudie C, Quittard PA, Bouhour F, Vial C, Garnier L, Fabien N. Comparison of commercial tests for detecting multiple anti-ganglioside autoantibodies in patients with well-characterized immune-mediated peripheral neuropathies. Clin Lab. 2013; 59:1277–1287.
Article
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