Ann Clin Neurophysiol.  2019 Jul;21(2):105-107. 10.14253/acn.2019.21.2.105.

Acute unilateral isolated abducens nerve palsy associated with anti-GM1 immunoglobulin M antibody

• Son H
• Kim A
• Hong SB
• Koo DL

• KMID: 2454733
• DOI: http://doi.org/10.14253/acn.2019.21.2.105

Abstract

Acute ophthalmoparesis that includes the oculomotor, trochlear, or abducens nerve may occur as an initial presentation of Miller Fisher syndrome (MFS). The symptoms of MFS or variant forms of Guillain-Barre syndrome are pathogenically related to anti-GQ1b antibodies. We report a case of a 36-year-old man with unilateral isolated abducens nerve palsy associated with anti-GM1 antibody. To the best of our knowledge, this is the first report of unilateral isolated abducens nerve palsy with positivity for anti-GM1 immunoglobulin M antibody.

Keyword

Abducens nerve; Ophthalmoplegia; Immunoglobulins

MeSH Terms

Abducens Nerve Diseases*
Abducens Nerve*
Adult
Antibodies
Guillain-Barre Syndrome
Humans
Immunoglobulin M*
Immunoglobulins*
Miller Fisher Syndrome
Ophthalmoplegia
Antibodies
Immunoglobulin M
Immunoglobulins

Figure

• 

  Fig. 1 Isolated abducens nerve palsy of the left eye. Lancaster tests illustrated an isolated abduction deficit of the left eye (paralytic strabismus). Red bars (the dotted line box from closed arrow) indicate normal positions of the right eye during left conjugate gaze. Green bars (the dotted line box from open arrow) represent abnormal positions of the left eye, which are deviated from red bars during left conjugate gaze.

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