J Audiol Otol.  2019 Jul;23(3):160-166. 10.7874/jao.2018.00514.

Severe Temporal Hyper-Activated States Caused by Noise in Tinnitus and Hyperacusis with Normal Hearing

Affiliations
  • 1Interdisciplinary Program in Brain-Science, Seoul National University, Seoul, Korea. junlee@snu.ac.kr
  • 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
  • 3Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

Lots of neuroimaging and animal studies have revealed that tinnitus and hyperacusis share the same patterns in the bottom up central auditory process. The aim was to identify the abnormal central patterns commonly observed in both tinnitus and hyperacusis in humans. We investigated two cases of normal hearing: a tinnitus patient and a hyperacusis patient. We compared the differences between the severe temporal hyper-activated state (STHS), with spikes, fast beta and gamma frequencies after noise exposure, and the mild temporal hyper-activated state (MTHS), in no sound exposed condition. The power of the gamma band in the two cases was increased in both auditory cortices compared to the other brain regions. Our results of human with normal hearing were the first to identify how tinnitus and hyperacusis caused by sound are abnormally active and how they maintain constant pathological states.

Keyword

Auditory cortex; Noise; Tinnitus; Hyperacusis; Electroencephalography

MeSH Terms

Animals
Auditory Cortex
Brain
Electroencephalography
Hearing*
Humans
Hyperacusis*
Neuroimaging
Noise*
Tinnitus*
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