Korean J Psychosom Med.  2019 Jun;27(1):60-68. 10.22722/KJPM.2019.27.1.60.

Association between Thyroid-Related Hormones and Cognitive Function in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Affiliations
  • 1Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. lkj@paik.ac.kr

Abstract


OBJECTIVES
The association between thyroid-related hormones and cognitive function has been controversial. The purpose of this study is to compare the levels of thyroid-related hormones in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Furthermore, we investigated the relationship between thyroid-related hormones and cognitive function.
METHODS
From January 2011 to December 2018, we retrospectively reviewed 105 patients who were diagnosed with AD and MCI by visiting a dementia clinic at Ilsan Paik Hospital. Thyroid-related hormones [triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH)] was measured using chemiluminescent immunoassay. An independent sample t-test was performed to analyze the mean value of thyroid-related hormones in patients of AD and MCI. To investigate whether thyroid-related hormones correlate significantly with Global deterioration scale (GDS), Clinical dementia rating (CDR) and scores of each The Korean version of the consortium to establish a registry for Alzheimer's disease items, we conducted a partial correlation analysis with geriatric depression scale-Korean version (GDS-K) scores as covariates.
RESULTS
There was no significant difference in the mean serum T3, T4 and TSH levels between patients of the AD and the MCI, but the Construction Praxis Test (CPT) showed a significant positive correlation with the serum TSH concentration (p-value=0.004).
CONCLUSIONS
In our study, the positive correlation between serum TSH level and the CPT associated with executive function was found to be helpful in understanding the association between thyroid-related hormones and the pathophysiology of dementia. Prospective studies in regard of the pathophysiology of thyroid-related hormones on cognitive function will be necessary in the future.

Keyword

Thyroid hormones; Alzheimer's disease; Mild cognitive impairment

MeSH Terms

Alzheimer Disease*
Cognition*
Dementia
Depression
Executive Function
Humans
Immunoassay
Mild Cognitive Impairment*
Prospective Studies
Retrospective Studies
Thyroid Hormones
Thyrotropin
Thyroxine
Thyroid Hormones
Thyrotropin
Thyroxine
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