Radiat Oncol J.
2019 Jun;37(2):82-90. 10.3857/roj.2019.00143.
Hypofractionated radiotherapy for early glottic cancer: a retrospective interim analysis of a single institution
- Affiliations
-
- 1Department of Radiation Oncology, Catholic University of Daegu, School of Medicine, Daegu, Korea.
- 2Department of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, Korea. jelee@knu.ac.kr
- 3Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.
- KMID: 2452568
- DOI: http://doi.org/10.3857/roj.2019.00143
Abstract
- PURPOSE
To evaluate the results of hypofractionated radiotherapy (HFX) for early glottic cancer.
MATERIALS AND METHODS
Eighty-five patients with cT1-2N0M0 squamous cell carcinoma of the glottis who had undergone HFX, performed using intensity-modulated radiotherapy (IMRT, n = 66) and three-dimensional conformal radiotherapy (3D CRT, n = 19) were analyzed. For all patients, radiotherapy was administered at 60.75 Gy in 27 fractions. Forty-three patients received a simultaneous integrated boost (SIB) of 2.3-2.5 Gy per tumor fraction.
RESULTS
The median follow-up duration was 29.9 months (range, 5.5 to 76.5 months). All patients achieved complete remission at a median of 50 days after the end of radiotherapy (range, 14 to 206 days). The 5-year rates for locoregional recurrence-free survival was 88.1%, and the 5-year overall survival rate was 86.2%. T2 stage was a prognostic factor for locoregional recurrence-free survival after radiotherapy (p = 0.002). SIB for the tumor did not affect disease control and survival (p = 0.191 and p = 0.387, respectively). No patients experienced acute or chronic toxicities of ≥grade 3. IMRT significantly decreased the dose administered to the carotid artery as opposed to 3D CRT (V₃₅, p < 0.001; V₅₀, p < 0.001).
CONCLUSIONS
Patients treated with HFX achieved acceptable locoregional disease control rates and overall survival rates compared with previous HFX studies. A fraction size of 2.25 Gy provided good disease control regardless of SIB administration.
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