Obstet Gynecol Sci.  2019 Jul;62(4):294-297. 10.5468/ogs.2019.62.4.294.

Leiomyoma development in Mayer-Rokitansky-Küster-Hauser syndrome: a case report and a narrative review of the literature

• Blontzos N
• Iavazzo C
• Vorgias G
• Kalinoglou N

• KMID: 2451661
• DOI: http://doi.org/10.5468/ogs.2019.62.4.294

Abstract

The development of leiomyomas on the grounds of an aplastic/hypoplastic uterus in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) has been rarely described. We report the first case of development of multiple leiomyomas in a patient with MRKHS complicated with pulmonary valve stenosis, and we present a narrative review of the existing literature. A 44-year-old patient with MRKHS attended our clinic because of pelvic pain, which was attributed to a pelvic mass found on ultrasound. Magnetic resonance imaging revealed a multinodular mass, indicating either ovarian pathology or the presence of leiomyomas. Exploratory laparotomy was performed, and multiple solid masses on the grounds of two rudimentary uterine buds were observed. Histological analysis revealed multiple leiomyomas arising from parametrial or paratubal tissue. We searched medical databases for articles relevant to leiomyomas and MRKHS. We present a review of the current literature and summarize the clinical manifestation, diagnosis, management, and histopathological findings of all the cases described. We underline that it is important for gynecologists to be aware of this rare clinical entity, and symptomatic leiomyomas cannot be excluded in patients with MRKHS.

Keyword

Mullerian duct failure; Rokitansky Kuster Hauser syndrome; Leiomyoma

MeSH Terms

Adult
Diagnosis
Humans
Laparotomy
Leiomyoma*
Magnetic Resonance Imaging
Pathology
Pelvic Pain
Pulmonary Valve Stenosis
Ultrasonography
Uterus

Figure

• 

  Fig. 1 Exploratory laparotomy findings.

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