Korean J Vet Res.  2019 Jun;59(2):89-96. 10.14405/kjvr.2019.59.2.89.

Prevalence and molecular characterization of novel recombinant enterovirus G isolates in Jeju Province of South Korea

• Jeon JH
• Lee C

• KMID: 2451643
• DOI: http://doi.org/10.14405/kjvr.2019.59.2.89

Abstract

Enterovirus species G (EV-G) is highly diverse, and is ubiquitous in pig populations, usually without diarrhea. The present study aimed to investigate the presence of novel EV-G recombinants with the torovirus papain-like cysteine protease (PLCP) in Jeju pig herds. EV-G1-PLCP mono-infections were most prevalent in diarrheic weaned piglets. The PLCP genes of the Jeju isolates varied in size and junction sequences, and were greatly heterogeneous, with 77.0-90.7% homology amongst all recombinants. Our results suggest that the exogenous PLCP gene has undergone continuous rapid mutation in the individual EV-G genomes following cross-order recombination, thereby causing clinical disease in swine.

Keyword

cross-order recombination; EV-G; PLCP; porcine diarrhea; torovirus

MeSH Terms

Cysteine Proteases
Diarrhea
Enterovirus*
Genome
Korea*
Prevalence*
Recombination, Genetic
Swine
Torovirus
Cysteine Proteases