Ann Dermatol.  2019 Aug;31(4):442-445. 10.5021/ad.2019.31.4.442.

Apocrine Hidrocystoma on the Penis: Report of a Case and Review of the Previous Cases

• Jo JW
• Yang JW
• Jeong DS

• KMID: 2451483
• DOI: http://doi.org/10.5021/ad.2019.31.4.442

Abstract

Apocrine hidrocystoma, also called apocrine cystadenoma, is a benign cystic tumor-like lesion that arises from the proliferation of apocrine glands. Clinically, it usually occurs singly as a unilocular or multilocular, dome-shaped translucent cyst. Histologically, it appears as unilocular or multilocular cysts composed of an inner layer of single or double layer of secretory columnar epithelium with decapitation secretion lying above an outer myoepithelial cell layer. Apocrine hidrocystomas mostly occur within the head and neck region and involvement of genitalia is extremely rare. This paper emphasizes the importance of considering the differential diagnosis of a genital cystic lesion. Herein, we report a case of apocrine hidrocystoma occurring in the penis and compare the clinicopathological characteristics of apocrine hidrocystoma in genitalia with the previous cases.

Keyword

Apocrine glands; Hidrocystoma; Penis

MeSH Terms

Apocrine Glands
Cystadenoma
Decapitation
Deception
Diagnosis, Differential
Epithelium
Genitalia
Head
Hidrocystoma*
Male
Neck
Penis*

Figure

• 

  Fig. 1 Clinical photograph of serpiginous cyst measuring about 4.0×0.3 cm on the penile shaft.

• 

  Fig. 2 Microscopic feature of apocrine hidrocystoma. (A) A cystic lesion in dermis is lined by (B) double layers of epithelial cells: an inner layer of cuboidal cells (black arrows) with apical snout (black arrowheads) and an outer layer of flattened cells (white arrows) with relatively small dark nucleus. The inner cells show cytoplasmic stains for (C) cytokeratin (CK) 7 and outer cells show nuclear stains for (D) p63, respectively. (E) CK20 and (F) carcinoembryonic antigen (CEA) are negative in both cells. (A) H&E, ×100, (B) H&E, ×400, (C) CK7, ×400, (D) p63, ×400, (E) CK20, ×400, (F) CEA, ×400.

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