J Korean Med Sci.
2019 Jul;34(26):e181. 10.3346/jkms.2019.34.e181.
Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea
- Affiliations
-
- 1Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea. psyjang@hanmail.net
- 2Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 3Department of Psychiatry, Gachon Medical School, Gachon University of Medicine and Science, Incheon, Korea.
- 4Department of Neuropsychiatry, Seoul Metropolitan Boramae Medical Center, Seoul, Korea.
- KMID: 2450980
- DOI: http://doi.org/10.3346/jkms.2019.34.e181
Abstract
- BACKGROUND
Panic disorder (PD) and major depressive disorder (MDD) can occur concurrently, despite different clinical manifestations. Because MDD and PD patients tend to have more complicated conditions, understanding the co-occurrence and pattern of these conditions is important. Here, we investigated the influence of PD and MDD on each other, with respect to time interval.
METHODS
Data from three national representative surveys were pooled (total 18,807 respondents), and the age of onset (AOO) of PD and MDD was analyzed. We performed Kaplan-Meier analysis to estimate separate survival functions, using the AOO of MDD and PD as the outcome. To understand the temporal effect of other disorders, we used a Cox proportional hazard model to estimate the hazard ratios for the onset of MDD/PD with other comorbidities as time-dependent covariates.
RESULTS
PD elevated the risk of subsequent MDD by 1.5-fold, whereas MDD elevated the risk of subsequent PD by 3.8-fold. The effect of such an elevation risk was significant for up to 2 years.
CONCLUSION
The results revealed a bidirectional relationship between MDD and PD. Each disease represents a risk of a subsequent occurrence of the other, which lasts for a considerable duration.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Comparison of Depressive Symptoms between Social Anxiety Disorder and Panic Disorder
- Association Study of the -36C>T Polymorphism in the Cholecystokinin Promoter Gene with the Diagnosis and the Response of Pharmacotherapy in Korean Patients with Panic Disorder
- Sleep in Panic Disorder and Nocturnal Panic Attack
- Diagnostic Utility of Minnesota Multiphasic Personality Inventory-2-Restructured Form Scales: Distinguishing Social Anxiety Disorder, Panic Disorder, and Major Depressive Disorder
- Association Study of A2a Adenosine Receptor Gene Polymorphism in Panic Disorder
