Investig Clin Urol.  2019 Jul;60(4):235-243. 10.4111/icu.2019.60.4.235.

Establishment of the Seoul National University Prospectively Enrolled Registry for Genitourinary Cancer (SUPER-GUC): A prospective, multidisciplinary, bio-bank linked cohort and research platform

• Jeong CW
• Suh J
• Yuk HD
• Tae BS
• Kim M
• Keam B
• Kim JH
• Kim SY
• Cho JY
• Kim SH
• Moon KC
• Cheon GJ
• Ku JH
• Kim HH
• Kwak C

• KMID: 2450540
• DOI: http://doi.org/10.4111/icu.2019.60.4.235

Abstract

PURPOSE
To establish a prospective, comprehensive, multidisciplinary, bio-bank linked genitourinary cancer cohort based on standard real practice.
MATERIALS AND METHODS
We established the Seoul National University Prospectively Enrolled Registry for Genitourinary Cancer (SUPER-GUC), a prospective cohort clinical database and bio-specimen repository system for prostate cancer (SUPER-PC), renal cell carcinoma (SUPER-RCC), and urothelial cancer (SUPER-UC) at a high-volume, tertiary institution. Each cohort consists of several sub-cohorts based on treatment or disease status. Detailed longitudinal clinical information, and general and disease specific patient-reported outcomes are captured. We use the same evaluation format and questionnaires for all participating departments. Patients' blood, urine, tumor, and normal tissues are collected. The number of registered patients and their basic characteristics are summarized. For the surgical sub-cohort, study participation, bio-specimen, and tissue banking rates are analyzed.
RESULTS
Since March 2016, 11 sub-cohorts for all disease statuses have been opened, ranging from low-risk localized to metastatic disease. SUPER-PC, SUPER-RCC, and SUPER-UC enrolled 929, 796, and 1,221 patients, respectively. Study participation, bio-sampling, and fresh frozen tumor banking rates of surgical sub-cohorts were 89.0% to 93.1%, 91.2% to 99.1%, and 56.9% to 79.1%, respectively.
CONCLUSIONS
SUPER-GUC is a study platform for comparative outcome, quality-of-life, and translational (genetics, biomarkers) research for genitourinary cancer.

Keyword

Biological specimen banks; Cohort studies; Prospective studies; Urogenital neoplasms

MeSH Terms

Biological Specimen Banks
Carcinoma, Renal Cell
Cohort Studies*
Humans
Prospective Studies*
Prostatic Neoplasms
Seoul*
Tissue Banks
Urogenital Neoplasms*

Figure

• 

  Fig. 1 Data collection process for the Seoul National University Prospectively Enrolled Registry for Prostate Cancer-Radical Prostatectomy (SUPER-PC–RP) with electronic case report forms. Preop., preoperative; character., characteristics; postop., postoperative; PO, postoperative; Qs, questionnaires; CARE, Convalescence And Recovery Evaluation; A/E, adverse events; PSA, prostate-specific antigen.

• 

  Fig. 2 Image captures of online interactive data visualization and analysis platform for Seoul National University Prospectively Enrolled Registry for Prostate Cancer-Radical Prostatectomy (SUPER-PC-RP). Dashboards are interactively changed when dimensional variables are changed in left panel. (A) Enrollment status, (B) operative methods and results, (C) pathologic outcomes, (D) example of interactive analysis. Pathologic Gleason Score by operative type and D'Amico classification.

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