Clin Endosc.  2019 May;52(3):252-257. 10.5946/ce.2018.151.

Efficacy of Endoscopic Submucosal Dissection of Esophageal Neoplasms under General Anesthesia

  • 1Department of Gastroenterology, Southern-Tohoku General Hospital, Koriyama, Japan.
  • 2Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
  • 3Department of Gastroenterology, Hyogo Prefectural Awaji Medical Center, Sumoto, Japan.
  • 4Department of Gastroenterology, Kitano Hospital, Osaka, Japan.
  • 5Department of Surgery, Southern-Tohoku General Hospital, Koriyama, Japan.


Evidence that general anesthesia (GA) reduces the operative time of esophageal endoscopic submucosal dissection (ESD) is currently insufficient. This study aims to evaluate the efficacy and safety of esophageal ESD under GA.
A total of 227 lesions from 198 consecutive patients with superficial esophageal neoplasms treated by ESD at 3 Japanese institutions between April 2011 and September 2017 were included in this retrospective study. For ESD, GA and deep sedation (DS) were used in 102 (51.5%, GA group) and 96 patients (48.5%, DS group), respectively.
There were no statistically significant differences in age, sex, or comorbidities between the groups. In the GA group, the tumor size was larger (21 [3-77] mm vs. 14 [3-63] mm, p<0.001), luminal circumference was larger (≥2/3; 13.9% vs. 5.4%, p=0.042), procedure time was shorter (28 [5-202] min vs. 40 [8-249] min, p<0.001), and submucosal dissection speed was faster (25.2 [7.8-157.2] mm² /min vs. 16.2 [2.4-41.3] mm² /min, p<0.001). The rates of intraoperative perforation and aspiration pneumonia were lower in the GA group, but the difference did not achieve statistical significance (p=0.242 and p=0.242).
GA shortens the procedure time of esophageal ESD.


Esophageal cancer; Endoscopic submucosal dissection; Anesthesia
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