J Korean Neuropsychiatr Assoc.  2019 May;58(2):146-150. 10.4306/jknpa.2019.58.2.146.

Alteration of White Matter Integrity in Dyslexic Children: Case-Control Study

• Park SY
• Yoo JH
• Yang M
• Kim B
• Kim BN

• KMID: 2449058
• DOI: http://doi.org/10.4306/jknpa.2019.58.2.146

Abstract

OBJECTIVES
To compare the white matter microstructure of dyslexic children with normal children using diffusion tensor imaging.
METHODS
Twenty one dyslexic children and 24 normal control children were recruited in the second and third grade of elementary school students. The fractional anisotropy (FA) values of 20 representative white matter tracts were estimated from the diffusion tensor imaging data of each subject using the Johns Hopkins University-white matter tractography atlas to determine the difference in white matter integrity between the dyslexic children and normal children.
RESULTS
Compared to the normal control group, the FA values of the left inferior longitudinal fasciculus [F(1,39)=5.908, p<0.05] and temporal part of the right superior longitudinal fasciculus [F(1,39)=7.328, p=0.010] were significantly higher in the dyslexic group and there was no significant difference in the other tracts.
CONCLUSION
In dyslexic children, compensatory pathways develop in the left inferior longitudinal fasciculus and in the temporal part of the right superior longitudinal fasciculus.

Keyword

Dyslexia; White matter tract; Diffusion tensor imaging; Diffusion tractography; Left inferior longitudinal fasciculus; Right superior longitudinal fasciculus

MeSH Terms

Anisotropy
Case-Control Studies*
Child*
Diffusion Tensor Imaging
Dyslexia
Humans
White Matter*