Int J Thyroidol.  2018 Nov;11(2):189-193. 10.11106/ijt.2018.11.2.189.

Two Cases of Papillary Carcinoma Arising from Thyroglossal Duct Cyst (TGDC)

• Jeong YJ
• Yum GH
• Kwon SY
• Oh KH

• KMID: 2448992
• DOI: http://doi.org/10.11106/ijt.2018.11.2.189

Abstract

A thyroglossal duct cyst (TGDC) is the most common congenital anomaly of the neck. However, carcinoma arising from TGDC is extremely rare. We report 2 cases of TGDC carcinoma. In the first case, a 21-year-old male patient complained of an anterior cervical mass; computed tomography (CT) and sonography revealed cystic mass that was suspected to be a TGDC. Sistrunk operation was performed. Papillary carcinoma was confirmed in pathologic examination. Additionally, he underwent total thyroidectomy and central neck dissection. After radioactive iodine ablation (RAI) was performed. In the second case, a 28-year-old male patient visited our out-patient department complaining of submental mass. He had already been diagnosed TGDC carcinoma 13 years ago and had undergone Sistrunk operation and total thyroidectomy. Malignancy was confirmed using fine-needle aspiration; thus, lateral neck dissection was performed and following this, he underwent RAI. Till date, no evidence of recurrence has been observed in these patients.

Keyword

Thyroglossal duct cyst; Thyroid; Papillary thyroid carcinoma

MeSH Terms

Adult
Biopsy, Fine-Needle
Carcinoma, Papillary*
Humans
Iodine
Male
Neck
Neck Dissection
Outpatients
Recurrence
Thyroglossal Cyst*
Thyroid Gland
Thyroidectomy
Young Adult
Iodine

Figure

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  Fig. 1. Profile photo. There was 5×3 cm-sized, movable, round mass in left anterior neck, hyoid level (black arrows).

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  Fig. 2. CT (A) and sono-graphic (B) finding. 4.1×2.6×2.8 cm nearly complete cystic nodule and 1.1 cm focal enhancing soft tissue within the cyst with stippled calcifi-cation were identified (white arrows).

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  Fig. 3. I-131 whole body scan. There was no remnant thyroid tissue or functioning metastasis.

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  Fig. 4. Profile photo. There was no other lesion except scars of previous Sistrunk operation and total thyroidectomy (black arrows).

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  Fig. 5. CT (A) and sono-graphic (B) finding. 2 cm- sized left submental cystic lesion (white arrows).

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  Fig. 6. Operation field and gross finding of main cystic mass. (A) The cystic mass was ovoid and soft. (B) Surgical field after operation.

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  Fig. 7. Histopathologic finding (H&E stain). (A) It shows pro-liferation of atypical papillary structures (∗) (×100). It suggests suspiciousness of papillary carcinoma. (B) Enlarged pathologic photo (×400).

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