Ann Rehabil Med.  2018 Dec;42(6):777-787. 10.5535/arm.2018.42.6.777.

The Persisted Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation to Augment Task-Specific Induced Hand Recovery Following Subacute Stroke: Extended Study

• Tretriluxana J
• Thanakamchokchai J
• Jalayondeja C
• Pakaprot N
• Tretriluxana S

• KMID: 2448898
• DOI: http://doi.org/10.5535/arm.2018.42.6.777

Abstract

OBJECTIVE
To examine the long-term effects of the low-frequency repetitive transcranial magnetic stimulation (LFrTMS) combined with task-specific training on paretic hand function following subacute stroke.
METHODS
Sixteen participants were randomly selected and grouped into two: the experimental group (real LFrTMS) and the control group (sham LF-rTMS). All the 16 participants were then taken through a 1-hour taskspecific training of the paretic hand. The corticospinal excitability (motor evoke potential [MEP] amplitude) of the non-lesioned hemisphere, and the paretic hand performance (Wolf Motor Function Test total movement time [WMFT-TMT]) were evaluated at baseline, after the LF-rTMS, immediately after task-specific training, 1 and 2 weeks after the training.
RESULTS
Groups comparisons showed a significant difference in the MEP after LF-rTMS and after the training. Compared to the baseline, the MEP of the experimental group significantly decreased after LF-rTMS and after the training and that effect was maintained for 2 weeks. Group comparisons showed significant difference in WMFT-TMT after the training. Only in the experimental group, the WMFT-TMT of the can lifting item significantly reduced compared to the baseline and the effect was sustained for 2 weeks.
CONCLUSION
The results of this study established that the improvement in paretic hand after task-specific training was enhanced by LF-rTMS and it persisted for at least 2 weeks.

Keyword

Brain stimulation; Hand function; Neural plasticity; Task-specific training; Stroke

MeSH Terms

Hand*
Lifting
Stroke*
Transcranial Magnetic Stimulation*

Figure

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  Fig. 1. CONSORT flow diagram.

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  Fig. 2. The Accelerated Skill Acquisition Program protocol.

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