Korean J Pancreas Biliary Tract.  2016 Jul;21(3):138-143. 10.15279/kpba.2016.21.3.138.

Xanthogranulomatous Pancreatitis Mimicking Pancreatic Cancer

  • 1Division of Gastroenterology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea. drkim@gilhospital.com
  • 2Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.


Xanthogranulomatous inflammation (XGI) is characterized histologically by the deposition of foamy macrophages and infiltration of inflammatory cells. While XGI is extremely rare, it has been reported in the gallbladder, kidney, stomach, and lymph nodes. A 61-year-old woman presented with epigastric pain for 2 weeks. Abdominal computed tomography and magnetic resonance imaging showed a pancreatic head mass with distal common bile duct wall thickening. Endoscopic ultrasonography followed by fine needle aspiration was performed, and subsequent pathology report revealed a benign disease. Because uncontrolled abdominal pain persisted and possibility of malignancy could not be excluded, Whipple's operation was eventually performed, and pathology report showed xanthogranulomatous pancreatitis (XGP). Herein, we report a case of symptomatic XGP mimicking of pancreas cancer. Although XGP is extremely rare, it should be considered as a differential diagnosis of neoplastic lesions of the pancreas.


Xanthogranulomatous; Pancreatitis; Neoplasm; Inflammation
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