Anesth Pain Med.  2019 Apr;14(2):180-186. 10.17085/apm.2019.14.2.180.

Effects of benzydamine hydrochloride spray on postoperative sore throat associated with double-lumen endobronchial intubation: a double-blind, randomized controlled clinical trial

• Park SH
• Son SG
• Kim ST

• KMID: 2447966
• DOI: http://doi.org/10.17085/apm.2019.14.2.180

Abstract

BACKGROUND
Postoperative sore throat is a common complication of endotracheal intubation; the thicker the endotracheal tube, the higher the frequency of postoperative sore throat. So, we evaluated the effect of benzydamine hydrochloride spray on postoperative sore throat, associated with double-lumen endobronchial intubation.
METHODS
Sixty patients undergoing thoracic surgery were scheduled and enrolled for intubation, with a double-lumen endobronchial tube. Of these patients, 30 were sprayed with benzydamine hydrochloride (group B), and 30 with normal saline (group N), 10 minutes before intubation was performed. Patients were randomly assigned to the two groups. Blood pressure and heart rate were recorded before, and after endotracheal intubation. Symptoms of sore throat, hoarseness, and dysphagia were examined one hour, as well as 24 hours, after surgery.
RESULTS
Incidence of sore throat was 73.3% and 23.3% (P < 0.001) in groups N and B, respectively, at one hour after surgery. In addition, incidence of sore throat at 24 hours after the operation, was also statistically significant (66.6% and 20.0%, P = 0.001). Frequency of dysphagia at one hour, and 24 hours after surgery, was lower in group B. There were no significant differences in heart rate, blood pressure, and hoarseness at 24 hours after surgery between the two groups.
CONCLUSIONS
In cases wherein a double-lumen endobronchial tube was used, an oropharyngeal spray of benzydamine hydrochloride before tracheal intubation, reduced incidence of postoperative sore throat.

Keyword

Benzydamine; Intubation, intratracheal; Pharyngitis; Postoperative period

MeSH Terms

Benzydamine*
Blood Pressure
Deglutition Disorders
Heart Rate
Hoarseness
Humans
Incidence
Intubation*
Intubation, Intratracheal
Pharyngitis*
Postoperative Period
Thoracic Surgery
Benzydamine

Figure

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  Fig. 1 Flow diagram of the patients.

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  Fig. 2 Comparison of cardiovascular changes. All values are expressed as mean ± SD. There were no significant differences between the two groups. Group N: normal saline spray, Group B: benzydamine hydrochloride spray. After intubation = just after the intubation; 1 minute = 1 minute after intubation; 3 minutes = 3 minutes after intubation; 5 minutes = 5 minutes after intubation.

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