Korean J Med.  2019 Apr;94(2):182-190. 10.3904/kjm.2019.94.2.182.

Analysis of Overall Survival According to Bone Marrow Aspiration Results in Non-Hodgkin's Lymphoma Patients

• Choi JY
• Kang KW
• Lee BH
• Yu ES
• Kim DS
• Lee SR
• Sung HJ
• Kim SJ
• Choi CW
• Kim BS
• Park Y

• KMID: 2446973
• DOI: http://doi.org/10.3904/kjm.2019.94.2.182

Abstract

BACKGROUND/AIMS
The staging work-up for patients with non-Hodgkin's lymphoma includes bone marrow aspiration and biopsy. Consistent results of both procedures can clarify the diagnosis. However, no clear guidelines have been established regarding positive results for bone marrow aspiration alone. The aim of this study was, therefore, to analyze the overall survival (OS) for the clinical diagnoses of these patients using morphological methods.
METHODS
We performed a retrospective analysis of patients who were consecutively enrolled in the Korea University Lymphoma Registry from 1991 to 2016. OS was compared according to the bone marrow group: without bone marrow involvement (BMA−/BMBx−), with positive results for aspiration and negative results for biopsy (BMA+/BMBx−), and with bone marrow involvement in biopsy (BMBx+). OS was assessed using the Kaplan-Meier method and multivariate analysis.
RESULTS
Of 1,735 patients, 1,326 were analyzed and 409 were excluded. In the Kaplan-Meier survival analysis, OS was significantly worse for patients in the BMBx+ group compared with those in the BMA−/BMBx− group (p < 0.001). However, there was no significant difference in OS between patients in the BMA+/BMBx− group and those in other groups (vs. BMA−/BMBx−, p = 0.163; BMBx+, p = 0.292). In multivariate analysis, by adjusting survival-related variables, the BMA+/BMBx− group showed marginal significance compared to the BMA−/BMBx− group (p = 0.081), and showed significance in the subgroup of indolent non-Hodgkin's lymphoma patients (p = 0.003).
CONCLUSIONS
This study suggested that even if there are positive results in bone marrow aspiration alone in patients with non-Hodgkin lymphoma, attention to patient characteristics, involving significance as a poor prognosis for OS, is required.

Keyword

Lymphoma, Non-Hodgkin; Biopsy; Bone marrow; Survival

MeSH Terms

Biopsy
Bone Marrow*
Diagnosis
Humans
Korea
Lymphoma
Lymphoma, Non-Hodgkin*
Methods
Multivariate Analysis
Prognosis
Retrospective Studies