Korean J Med.  2019 Apr;94(2):159-169. 10.3904/kjm.2019.94.2.159.

Vascular Calcification in Patients with Chronic Kidney Disease

Affiliations
  • 1Division of Nephrology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea. jyjung@gachon.ac.kr

Abstract

Cardiovascular morbidity and mortality are very common in patients with chronic kidney disease, which may result in part from vascular calcification. Vascular calcification requires osteoblastic trans-differentiation of vascular smooth muscle cells through an active and highly regulated process that is morphologically and functionally similar to bone formation in a number of ways. Multiple studies have been published on this topic, but the precise mechanism of vascular calcification remains unclear. This review presents recent insights into the mechanism of vascular calcification, as well as therapies that modulate mineral metabolism.

Keyword

Vascular calcification; Chronic kidney disease; Vascular smooth muscle; Trans-differentiation; Mineralization

MeSH Terms

Humans
Metabolism
Miners
Mortality
Muscle, Smooth, Vascular
Osteoblasts
Osteogenesis
Renal Insufficiency, Chronic*
Vascular Calcification*
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