Mood Emot.  2018 Mar;16(1):38-43. 10.0000/me.2018.16.1.38.

Relationship between Suicidal Ideation and Plasma C-Reactive Protein Level in General Population : The Korean National Health and Nutrition Examination Survey

• Lee JA
• Park SC
• Kim GM
• Lee BJ
• Park SW
• Seo MK
• Lee JG

• KMID: 2446844
• DOI: http://doi.org/10.0000/me.2018.16.1.38

Abstract

OBJECTIVES
The purpose of this study is to inquire into the relationship between the association of suicidal ideation and the plasma C-reactive protein level in the general population.
METHODS
This study selected a total of 5,090 subjects who have responded to the survey item on suicidal ideation status, and received the plasma C-reactive protein test, as a research subject using the 2015 data of the National Health and Nutrition Survey. This study conducted a covariance analysis by correcting a potential influence of demographic and hematological factors. Besides, this study intended to define the cut-off value of the optimum plasma C-reactive protein level, which once identified can distinguish between a subject with and without suicidal ideation using the model of the decision tree.
RESULTS
The Plasma C-reactive protein level of a subject having suicidal ideation was noted as being significantly higher than the one having no suicidal ideation in the covariance analysis (p=0.046). In addition, the proper cut-off value of the plasma C-reactive protein level between the subjects with and without suicidal ideation was found to be 1.30 mg/L (p=0.003).
CONCLUSION
It is noted that the high plasma C-reactive protein level showed a significant correlation with individuals with noted suicidal ideation. In addition, this study has significance in that it presented that the plasma C-reactive protein concentration has the possibility as an accurate and significant marker of suicidal ideation in the general population.

Keyword

C-reactive protein (CRP); Decision tree; General population; Plasma; Suicidal ideation

MeSH Terms

C-Reactive Protein*
Decision Trees
Humans
Nutrition Surveys*
Plasma*
Research Subjects
Suicidal Ideation*
C-Reactive Protein