J Korean Ophthalmol Soc.  2019 May;60(5):491-495. 10.3341/jkos.2019.60.5.491.

Bilateral Rhegmatogenous Retinal Detachments after Systemic Pazopanib Treatment

Affiliations
  • 1Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Korea. eunjee095@gmail.com
  • 3Divison of Oncology-Hematology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

Abstract

PURPOSE
A case of bilateral rhegmatogenous retinal detachment is reported after pazopanib treatment of a patient with breast angiosarcoma.
CASE SUMMARY
A 53-year-old female presented with bleeding in a right breast mass prior to an emergency room visit. She was diagnosed with metastatic breast angiosarcoma after a breast mass biopsy. She was treated with paclitaxel and radiation therapy. Systemic pazopanib treatment was added to treat lung metastasis. After 3 weeks, she felt sudden floaters in her right eye. In her fundus examination, there was vitreous hemorrhage, but no retinal detachment was noted. Five weeks later, she visited the clinic for a bilateral temporal visual field defect. A fundus examination showed bilateral retinal detachments with superonasal retinal tears. Both the patient and her family did not want surgery for her systemic condition because of her terminal cancer.
CONCLUSIONS
Retinal detachment has been reported as a rare complication after systemic pazopanib treatment, but there has been no previous report in the Republic of Korea, therefore this is the first case of bilateral retinal detachments after systemic pazopanib treatment.

Keyword

Anti-VEGF treatment; Pazopanib; Retinal detachment; Retinal tear

MeSH Terms

Biopsy
Breast
Emergency Service, Hospital
Female
Hemangiosarcoma
Hemorrhage
Humans
Lung
Middle Aged
Neoplasm Metastasis
Paclitaxel
Republic of Korea
Retinal Detachment*
Retinal Perforations
Retinaldehyde*
Visual Fields
Vitreous Hemorrhage
Paclitaxel
Retinaldehyde
Full Text Links
  • JKOS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error