Clin Nutr Res.  2019 Apr;8(2):148-158. 10.7762/cnr.2019.8.2.148.

Associations between Muscle Strength with Different Measures of Obesity and Lipid Profiles in Men and Women: Results from RaNCD Cohort Study

Affiliations
  • 1Department of Nutrition, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • 2Department of Epidemiology, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • 3Department of Nutrition, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • 4Department of Health Promotion, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. behrooz.hamzeh@kums.ac.ir

Abstract

We aimed to examine associations between muscle strength and obesity and serum lipid profile in Ravansar Non-Communicable Disease (RaNCD) cohort study. This study was conducted on 6,455 subjects aged 35-65 years old from baseline data of RaNCD in Iran. The associations between grip strength and adiposity measurements were explored using linear regression with adjustment for age, height, smoking status, alcohol intake, social class, and prevalent disease. The mean of body mass index (BMI) and muscle strength was 27.2 ± 4.6 kg/m² and 33.3 ± 11.5, respectively. Muscular strength increased with increasing BMI and waist circumference (WC) in both sexes. Multivariate regression analysis revealed a 3.24 (95% confidence interval [CI], 2.29, 4.19) kg difference between BMI in top and bottom in men, and 1.71 (95% CI, 0.98, 2.34) kg/m² in women. After multivariable adjustment, a difference of 2.04 (95% CI, 1.12, 2.97) kg was observed between the top and bottom WC quartiles in men and 1.25 (95% CI, 0.51, 1.98) kg in women. In men, with increase of low-density lipoprotein and cholesterol, the mean muscle strength was significantly increased. Muscle strength may be associated with body composition and lipid profiles. Muscle strength can be an appropriate indicator for predicting some of the problems caused by body composition disorders, which requires further longitudinal studies.

Keyword

Muscle strength; Abdominal obesity; Body mass index; Visceral fat

MeSH Terms

Adiposity
Body Composition
Body Mass Index
Cholesterol
Cohort Studies*
Female
Hand Strength
Humans
Intra-Abdominal Fat
Iran
Linear Models
Lipoproteins
Longitudinal Studies
Male
Muscle Strength*
Obesity*
Obesity, Abdominal
Smoke
Smoking
Social Class
Waist Circumference
Cholesterol
Lipoproteins
Smoke

Figure

  • Figure 1 Mean of grip strength by tertile of BMI and WC in men and women. Mean of grip strength (kg) increases with increasing WC in all of the BMI in men (A) and women (B). Bars indicate 95% confidence intervals. Mean of grip strength adjusted for age and height. BMI tertiles, men: < 25.4 kg/m2; 25.4–28.1 kg/m2; > 28.1 kg/ m2; women: < 24.2 kg/m2; 24.2–27.7 kg/m2; > 27.7 kg/m2. WC tertiles, men: < 96.1 cm; 96.1–103.7 cm;> 103.7 cm; women: < 83.5 cm; 83.5–93.8 cm; > 93.8 cm. BMI, body mass index; WC, waist circumference.


Reference

1. Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, Leveille SG, Fried LP, Md JM. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc. 2002; 50:1947–1954.
Article
2. Kim JH, Lim S, Choi SH, Kim KM, Yoon JW, Kim KW, Lim JY, Park KS, Jang HC, Kritchevsky S. Sarcopenia: an independent predictor of mortality in community-dwelling older Korean men. J Gerontol A Biol Sci Med Sci. 2014; 69:1244–1252.
Article
3. Gregorio L, Brindisi J, Kleppinger A, Sullivan R, Mangano KM, Bihuniak JD, Kenny AM, Kerstetter JE, Insogna KL. Adequate dietary protein is associated with better physical performance among post-menopausal women 60–90 years. J Nutr Health Aging. 2014; 18:155–160.
Article
4. Bisschop CN, Peeters PH, Monninkhof EM, van der Schouw YT, May AM. Associations of visceral fat, physical activity and muscle strength with the metabolic syndrome. Maturitas. 2013; 76:139–145.
Article
5. Hossain SM, Maggio DM, Sullivan KM. Relationship between food aid and acute malnutrition following an earthquake. Food Nutr Bull. 2009; 30:336–339.
Article
6. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011; 377:557–567.
Article
7. Roubenoff R. Sarcopenic obesity: the confluence of two epidemics. Obes Res. 2004; 12:887–888.
Article
8. Jackson AW, Lee DC, Sui X, Morrow JR Jr, Church TS, Maslow AL, Blair SN. Muscular strength is inversely related to prevalence and incidence of obesity in adult men. Obesity (Silver Spring). 2010; 18:1988–1995.
Article
9. Keevil VL, Luben R, Dalzell N, Hayat S, Sayer AA, Wareham NJ, Khaw KT. Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British cohort study. J Nutr Health Aging. 2015; 19:3–11.
Article
10. Volaklis KA, Halle M, Thorand B, Peters A, Ladwig KH, Schulz H, Koenig W, Meisinger C. Handgrip strength is inversely and independently associated with multimorbidity among older women: results from the KORA-Age study. Eur J Intern Med. 2016; 31:35–40.
Article
11. Sayer AA, Syddall HE, Dennison EM, Martin HJ, Phillips DI, Cooper C, Byrne CD. Hertfordshire Cohort. Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study. QJM. 2007; 100:707–713.
Article
12. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med. 2006; 23:469–480.
Article
13. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, van der Schouw YT, Spencer E, Moons KG, Tjønneland A, Halkjaer J, Jensen MK, Stegger J, Clavel-Chapelon F, Boutron-Ruault MC, Chajes V, Linseisen J, Kaaks R, Trichopoulou A, Trichopoulos D, Bamia C, Sieri S, Palli D, Tumino R, Vineis P, Panico S, Peeters PH, May AM, Bueno-de-Mesquita HB, van Duijnhoven FJ, Hallmans G, Weinehall L, Manjer J, Hedblad B, Lund E, Agudo A, Arriola L, Barricarte A, Navarro C, Martinez C, Quirós JR, Key T, Bingham S, Khaw KT, Boffetta P, Jenab M, Ferrari P, Riboli E. General and abdominal adiposity and risk of death in Europe. N Engl J Med. 2008; 359:2105–2120.
Article
14. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L, Tanomsup S, Wangai P Jr, Razak F, Sharma AM, Anand SS. INTERHEART Study Investigators. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005; 366:1640–1649.
Article
15. Gubelmann C, Vollenweider P, Marques-Vidal P. Association of grip strength with cardiovascular risk markers. Eur J Prev Cardiol. 2017; 24:514–521.
Article
16. García-Artero E, Ortega FB, Ruiz JR, Mesa JL, Delgado M, González-Gross M, García-Fuentes M, Vicente-Rodríguez G, Gutiérrez A, Castillo MJ. Lipid and metabolic profiles in adolescents are affected more by physical fitness than physical activity (AVENA study). Rev Esp Cardiol. 2007; 60:581–588.
17. Peterson MD, Duchowny K, Meng Q, Wang Y, Chen X, Zhao Y. Low normalized grip strength is a biomarker for cardiometabolic disease and physical disabilities among US and Chinese adults. J Gerontol A Biol Sci Med Sci. 2017; 72:1525–1531.
Article
18. Andrade S, Ochoa-Avilés A, Lachat C, Escobar P, Verstraeten R, Van Camp J, Donoso S, Rojas R, Cardon G, Kolsteren P. Physical fitness among urban and rural Ecuadorian adolescents and its association with blood lipids: a cross sectional study. BMC Pediatr. 2014; 14:106.
Article
19. Frederiksen H, Hjelmborg J, Mortensen J, McGue M, Vaupel JW, Christensen K. Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102. Ann Epidemiol. 2006; 16:554–562.
Article
20. Eghtesad S, Mohammadi Z, Shayanrad A, Faramarzi E, Joukar F, Hamzeh B, Farjam M, Zare Sakhvidi MJ, Miri-Monjar M, Moosazadeh M, Hakimi H, Rahimi Kazerooni S, Cheraghian B, Ahmadi A, Nejatizadeh A, Mohebbi I, Pourfarzi F, Roozafzai F, Motamed-Gorji N, Montazeri SA, Masoudi S, Amin-Esmaeili M, Danaie N, Mirhafez SR, Hashemi H, Poustchi H, Malekzadeh R. The PERSIAN cohort: providing the evidence needed for healthcare reform. Arch Iran Med. 2017; 20:691–695.
21. Poustchi H, Eghtesad S, Kamangar F, Etemadi A, Keshtkar AA, Hekmatdoost A, Mohammadi Z, Mahmoudi Z, Shayanrad A, Roozafzai F, Sheikh M, Jalaeikhoo A, Somi MH, Mansour-Ghanaei F, Najafi F, Bahramali E, Mehrparvar A, Ansari-Moghaddam A, Enayati AA, Esmaeili Nadimi A, Rezaianzadeh A, Saki N, Alipour F, Kelishadi R, Rahimi-Movaghar A, Aminisani N, Boffetta P, Malekzadeh R. Prospective Epidemiological Research Studies in IrAN (the PERSIAN cohort): rationale, objectives and design. Am J Epidemiol. 2018; 187:647–655.
Article
22. Hardy R, Cooper R, Aihie Sayer A, Ben-Shlomo Y, Cooper C, Deary IJ, Demakakos P, Gallacher J, Martin RM, McNeill G, Starr JM, Steptoe A, Syddall H, Kuh D. HALCyon study team. Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. PLoS One. 2013; 8:e56483.
Article
23. Marcus RL, Addison O, Dibble LE, Foreman KB, Morrell G, Lastayo P. Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals. J Aging Res. 2012; 2012:629637.
Article
24. Hsiao PY, Mitchell DC, Coffman DL, Craig Wood G, Hartman TJ, Still C, Jensen GL. Dietary patterns and relationship to obesity-related health outcomes and mortality in adults 75 years of age or greater. J Nutr Health Aging. 2013; 17:566–572.
Article
25. Otten L, Bosy-Westphal A, Ordemann J, Rothkegel E, Stobäus N, Elbelt U, Norman K. Abdominal fat distribution differently affects muscle strength of the upper and lower extremities in women. Eur J Clin Nutr. 2017; 71:372–376.
Article
26. Yamada E, Takeuchi M, Kurata M, Tsuboi A, Kazumi T, Fukuo K. Low haemoglobin levels contribute to low grip strength independent of low-grade inflammation in Japanese elderly women. Asia Pac J Clin Nutr. 2015; 24:444–451.
27. Bucci L, Yani SL, Fabbri C, Bijlsma AY, Maier AB, Meskers CG, Narici MV, Jones DA, McPhee JS, Seppet E, Gapeyeva H, Pääsuke M, Sipilä S, Kovanen V, Stenroth L, Musarò A, Hogrel JY, Barnouin Y, Butler-Browne G, Capri M, Franceschi C, Salvioli S. Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects. Biogerontology. 2013; 14:261–272.
Article
Full Text Links
  • CNR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr