J Periodontal Implant Sci.  2019 Apr;49(2):105-113. 10.5051/jpis.2019.49.2.105.

The role of serum lipoxin A4 levels in the association between periodontal disease and metabolic syndrome

Affiliations
  • 1Department of Periodontology, Mustafa Kemal University Faculty of Dentistry, Hatay, Turkey. burakdogann@gmail.com
  • 2Department of Periodontology, Süleyman Demirel University Faculty of Dentistry, Isparta, Turkey.

Abstract

PURPOSE
An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS.
METHODS
Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses.
RESULTS
Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL).
CONCLUSIONS
The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.

Keyword

Inflammation; Lipoxins; Metabolic syndrome X; Periodontal diseases

MeSH Terms

Body Mass Index
Diagnosis
Humans
Inflammation
Linear Models
Lipoxins*
Metabolic Syndrome X
Periodontal Diseases*
Periodontal Index
Lipoxins

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