Dement Neurocogn Disord.  2015 Mar;14(1):12-16. 10.12779/dnd.2015.14.1.12.

Risk Factors for Post-Lumbar Puncture Headache in a Study of Alzheimer's Disease Biomarkers

Affiliations
  • 1Clinical Neuroscience Center, Seoul National University Bundang Hospital, Department of Neurology, Seoul National University College of Medicine, Seongnam, Korea. neuroksy@snu.ac.kr
  • 2Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea.
  • 3Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

BACKGROUND AND PURPOSE
In memory clinics, the lumbar puncture (LP) is increasingly being used to evaluate cerebrospinal fluid for biomarkers of Alzheimer's disease (AD). Post-lumbar puncture headache (PLPH) is the most frequent complication of LP, and can prove to be a barrier for the performance of LP.
METHODS
We retrospectively collected data from 59 subjects (patients with AD and cognitively healthy controls) who were enrolled in a study aimed to identify AD biomarkers via LP. In order to determine whether subjects experienced PLPH, we assessed recorded follow-up telephone interviews. To analyze the association between the occurrence of PLPH and several demographic- and procedure-related factors, a multiple logistic regression analysis with backward stepwise method was performed.
RESULTS
The overall frequency of PLPH was 49.15%. PLPH was more frequent in younger subjects and clinical diagnosis was associated with PLPH. The use of cutting-edge needles was also suggested as a statistically significant factor in the development of PLPH, and was determined to be the only factor that could be modified in order to lower the frequency of PLPH.
CONCLUSIONS
Age, clinical diagnosis, and needle type were all determined to be predictive factors of PLPH.

Keyword

post-lumbar puncture headache; Alzheimer's disease; risk factor

MeSH Terms

Alzheimer Disease*
Biomarkers*
Cerebrospinal Fluid
Diagnosis
Follow-Up Studies
Interviews as Topic
Logistic Models
Memory
Needles
Post-Dural Puncture Headache*
Retrospective Studies
Risk Factors*
Spinal Puncture
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