Dement Neurocogn Disord.  2018 Sep;17(3):110-119. 10.12779/dnd.2018.17.3.110.

¹⁸F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia

  • 1Department of Neurology, Inha University School of Medicine, Incheon, Korea.
  • 2Neuroscience Research Institute, Gachon University, Incheon, Korea.
  • 3Department of Neuroscience, Gachon University College of Medicine, Incheon, Korea.
  • 4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 5Department of Neurology, Seoul Medical Center, Seoul, Korea.
  • 6Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea.
  • 7Tohoku Medical and Pharmaceutical University, Sendai, Japan.
  • 8Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
  • 9Department of Health Science and Technology, GAIHST, Gachon University, Incheon, Korea.


To analyze 18F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA).
Thirty-one participants, including those with Alzheimer's disease (AD, n=13), navPPA (n=3), and those with normal control (NC, n=15) who completed 3 Tesla magnetic resonance imaging, 18F-THK5351 PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of 18F-THK5351 in navPPA patients.
In ROI-based analysis, patients with navPPA had higher levels of THK retention in the Broca's area, bilateral inferior frontal lobes, bilateral precentral gyri, and bilateral basal ganglia. Patients with navPPA showed higher levels of THK retention in bilateral frontal lobes (mainly left side) compared than NC in voxel-wise analysis.
In our study, THK retention in navPPA patients was mainly distributed at the frontal region which was well correlated with functional-radiological distribution of navPPA. Our results suggest that tau PET imaging could be a supportive tool for diagnosis of navPPA in combination with a clinical history.


Primary Progressive Nonfluent Aphasia; tau Protein; Neurofibrillary Tangles; Positron Emission Tomography

MeSH Terms

Alzheimer Disease
Aphasia, Primary Progressive*
Basal Ganglia
Broca Area
Frontal Lobe
Magnetic Resonance Imaging
Neurofibrillary Tangles
Neuropsychological Tests
Positron-Emission Tomography
Primary Progressive Nonfluent Aphasia
tau Proteins
tau Proteins
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