Korean J Gastroenterol.  2019 Mar;73(3):190-191. 10.4166/kjg.2019.73.3.190.

New Concept of Hepatocellular Carcinoma Treatment with the Tumor Suppressor ‘WDR76’ through ‘RAS’ Degradation

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. DRPJY@yuhs.ac

Abstract

No abstract available.


MeSH Terms

Carcinoma, Hepatocellular*

Reference

1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136:E359–E386.
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2. Jeong WJ, Park JC, Kim WS, et al. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nat Commun. 2019; 10:295.
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3. Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer. 2011; 11:761–774.
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4. Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol. 2011; 13:39–51.
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